Protein Alignment TBXAS1 and Cyp6a19

DIOPT Version :9

• Sequence 1: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 588
• Identity: 144/588 - (24%)
• Similarity: 268/588 - (45%)
• Gaps: 120/588 - (20%)

Human    16 VTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQ----------MEL 70
            :.:.|.|.:|.|:.|:....::..::.|:.|..|:..:||    ....|.:.          ::.
  Fly     3 ILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGN----TGELWRTMPLAGILKRTYLKF 63

Human    71 RK-LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS----VADSVLFLRDK 130
            || ..||..|:||....:|||::.|.:|.||:.:|..|.:|   |:....    :.:::..:..:
  Fly    64 RKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDR---GVYHNEKDDPLTNNLATIEGQ 125

Human   131 RWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPF 195
            :|:.:|..|...|:..|:..:...::      ::|.:
  Fly   126 KWKNLRQKLTHTFTSAKMKSMFSTVL------NVGDE---------------------------- 156

Human   196 CMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCK 260
             |:.::.:          :.:.|....::......:|:||:...|||...:|.:.|:..||:
  Fly   157 -MIRVVDE----------KISSSSQTLEVTDIVSRFTSDVIGICAFGLKCNSLRDPKAEFVQ--- 207

Human   261 RFFEFCIPRP------ILVLLLSFPSIMVPLA--RILPNKNRDELNGFFNKLIRNVIALRDQQAA 317
              ..:...|.      :.:|:...|.:.|.|.  .:||:..:     |:.|::::.|..|.::
  Fly   208 --MGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSVQK-----FYMKIVQDTIDYRMKR-- 263

Human   318 EERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAF 382
            :..|.||:..::|.:        |.:|        .|.|.|            .|..:|:..|||
  Fly   264 KVTRNDFMDTLIDMK--------QQYD--------KGDKEN------------GLAFNEVAAQAF 300

Human   383 IFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP-EFCSLEEGLPYLDMVIAET 446
            :|.:||:|..:.|:.|..|.||.|.|.|:||..|:|...|::... |:.|::: |.|::.||.|:
  Fly   301 VFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQD-LFYMEKVINES 364

Human   447 LRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQ 509
            ||.:|......|.|.:..:....:  |.||..:.::...:|||||.:|.||.|.||||..|..::
  Fly   365 LRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKK 429

Human   510 HRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLE-SKSALGPKNGVY 573
            .....:||||||||:|:|:|.|.::|.:.|..::|.|||:..|:|.||::.. :...||.:.|::
  Fly   430 RPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSEGGIH 494

Human   574 IKI 576
            :.|
  Fly   495 LNI 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	136/555 (25%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	137/555 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820