Protein Alignment TBXAS1 and Cyp9h1

DIOPT Version :9

• Sequence 1: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_610820.1
• Gene: Cyp9h1 / 36412
• FlyBaseID: FBgn0033775
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 159/597 - (26%)
• Similarity: 277/597 - (46%)
• Gaps: 116/597 - (19%)

Human    15 MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLY----- 74
            |:.:||.:.||.||..:|.:.:....:.|:.|.||.|.|||:..  :........|:|:.
  Fly     5 MIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPL--KAMIGGMPVLKKMIELHTK 67

Human    75 ---GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR--MASGLEFKSVADSVLFLRDKRWEE 134
               .|:.|.|..|.....:.:|::||.:.::.|.:|.|.  |.:.::...::.|::.|||.||:|
  Fly    68 HTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDGRWKE 132

Human   135 VRGALMSAFSPEKL----------NELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLH 189
            :|..|..||:..|:          :|.|::.:||:::
  Fly   133 MRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLE---------------------------- 169

Human   190 YATLPFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDP 254
                       :||...:.| .:|.|            :..:..||:|:||||..::|::..::.
  Fly   170 -----------LSQDASIEL-EMKDY------------FTRFANDVIATVAFGISINSFRRKDNE 210

Human   255 FVK---HCKRFFEFCIPRPILVLLLSFPSIMVPL-ARILPNKNRDELNGFFNKLIRNVIALRDQQ 315
            |.:   ...|...:.:.:.:|..|  ||.:|..| .::|..||.|    :|:.|:  ..|:|.:|
  Fly   211 FFRIGQAMSRISAWSVVKAMLYAL--FPRLMKVLRIQVLDTKNID----YFSSLV--TAAMRYRQ 267

Human   316 AAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQ 380
            ..:..|.|.:.::::|:...          :.|:          |.:.:........|.|:::.|
  Fly   268 EHKVVRPDMIHLLMEAKQQR----------LADL----------SDKSKDELYYSEFTADDLLAQ 312

Human   381 AFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLRE-VDVFKEKHMAPEFCSLEEGLPYLDMVIA 444
            ..:|..||:|||:::|.|.|:.|..||..|::|..| :.|.:|....|........:.|||||:.
  Fly   313 CLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVL 377

Human   445 ETLRMYPPAFRFTREAAQDCEVL---GQRI---PAGAVLEMAVGALHHDPEHWPSPETFNPERFT 503
            |.||.:||:....||..||.::.   ||::   ..|.||::.:.:||||||::..||.||||||.
  Fly   378 EALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFA 442

Human   504 AEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKS-ALG 567
            .....:.|  .|:|||.|||:|:|.|:.|:|:|..:..:|..|:......|...|..:.:. .|.
  Fly   443 DGHALESR--VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLK 505

Human   568 PKNGVYIKIVSR 579
            ||||.::|..:|
  Fly   506 PKNGFWLKFEAR 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	147/560 (26%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	147/557 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	1	0.950	-	0	Normalized mean entropy	S4378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820