Protein Alignment TBXAS1 and Cyp6a13

DIOPT Version :9

• Sequence 1: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_610390.1
• Gene: Cyp6a13 / 35837
• FlyBaseID: FBgn0033304
• Length: 493
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 162/580 - (27%)
• Similarity: 272/580 - (46%)
• Gaps: 114/580 - (19%)

Human    15 MVTVALSVALL--ALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMEL---RKLY 74
            ::.:..:|.||  ..|:|:    :|...:.|:...:|..|.||::...:....:.:.|   ||..
  Fly     4 LLVLVFTVGLLLYVKLRWH----YSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFR 64

Human    75 G--PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVAD-----SVLFLRDKRW 132
            |  ..|||:......:.|.:.::|:.:::.:||:|.:|   || |.:|.|     ::|||....|
  Fly    65 GVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADR---GL-FHNVRDDPLTGNLLFLDGPEW 125

Human   133 EEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCM 197
            ..:|..|...|:..|:                            :...|:.:.|.
  Fly   126 RWLRQNLTQVFTSGKM----------------------------KFMFPNMVEVG---------- 152

Human   198 VPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRF 262
             ..::|||.|.:..:       :|.|:  | ..:||||:.|.|||...:|.|.||..|    :|.
  Fly   153 -EKLTQACRLQVGEI-------EAKDL--C-ARFTTDVIGSCAFGLECNSLQDPESQF----RRM 202

Human   263 FEFCIPRPI-LVLLLSFPSIMVPLARILPNK-NRDELNGFFNKLIRNVIALRDQQAAEERRRDFL 325
            .......|: .||:.:|......|||.|..: .|.|::.||...:|..:..|.::  ...|.|.:
  Fly   203 GRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQTLDYRRRE--NIHRNDLI 265

Human   326 QMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYE 390
            |::::....    ||:|                            .|:.::|..||.:|.:||::
  Fly   266 QLLMELGEE----GVKD----------------------------ALSFEQIAAQALVFFLAGFD 298

Human   391 IITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAF 454
            ..:.|:||..|.||.|||.||:|..|| .|.|..:....:.|::| :||||.|:|||||.||...
  Fly   299 TSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQE-MPYLDQVVAETLRKYPILP 362

Human   455 RFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLP 517
            ...|.:.::.::....  :..|:.:.:.|.::|||||.:|.||.|:|.||..|..:...||.|||
  Fly   363 HLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLP 427

Human   518 FGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSAL-GPKNGVYIKI 576
            ||.|||:|:|.|.|.|:||:.|:::|..|:|....:||:||:..|::.| ..:.||::::
  Fly   428 FGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRM 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	155/544 (28%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	152/534 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820