DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBXAS1 and Cyp9b2

DIOPT Version :9

Sequence 1:NP_001159725.2 Gene:TBXAS1 / 6916 HGNCID:11609 Length:579 Species:Homo sapiens
Sequence 2:NP_523646.1 Gene:Cyp9b2 / 35635 FlyBaseID:FBgn0015039 Length:505 Species:Drosophila melanogaster


Alignment Length:610 Identity:155/610 - (25%)
Similarity:269/610 - (44%) Gaps:153/610 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    15 MVTVALSVALLALL--KWYSTSAFSRLEKLGLRHPKPSPFIGNL--------TFFRQ--GFWESQ 67
            ::.:.|::.::..|  || ||:.|...|:..|...||.||:||:        :|.||  .|:|  
  Fly     3 LIEICLALVVIGYLIYKW-STATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEFYE-- 64

Human    68 MELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRM----ASGLEFKSVADSVLFLR 128
               |.....|.|::..|...|.:::|::||:|.|::|.:|.|..    ::...|.   |.:..:|
  Fly    65 ---RTRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFN---DMLSVMR 123

Human   129 DKRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATL 193
            |:||:.:|..|...|:..|:..                                           
  Fly   124 DQRWKHMRNTLTPVFTAAKMRN------------------------------------------- 145

Human   194 PFCMVPLISQACDLLLAHLKRYAES---GDAFDI-QRCYCN-YTTDVVASVAFGTPVDSWQAPED 253
               |..|::::....|.||...:::   ...|:: .:..|| .:.|::|:.|||..|:|:..|::
  Fly   146 ---MFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDIIATTAFGLKVNSYDNPKN 207

Human   254 PFVK--------HCKRFFEF----CIPRPILVLLLS-FPSIMVPLARILPNKNRDELNGFFNKLI 305
            .|.:        ...:||:|    .:|:...:|.|: |.|..|               .:|.:|:
  Fly   208 EFYEIGQSLVFSRGLQFFKFMLSTLVPKLFSLLKLTIFDSAKV---------------DYFARLV 257

Human   306 RNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMAR 370
              |.|::.::.....|.|.:|::::|::.:..                                 
  Fly   258 --VEAMQYREKHNITRPDMIQLLMEAKNESED--------------------------------- 287

Human   371 PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLRE-VDVFKEKHMAPEFCSLEE 434
            ..|.||||.|.|||..|.:|..:|.:...||.|..|||.||:|..| |:..|..:.||......:
  Fly   288 KWTDDEIVAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQ 352

Human   435 GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL---GQRI---PAGAVLEMAVGALHHDPEHWPS 493
            .:.|:||||:|:||.:..|....|..::|..:.   |.::   ..|..:.:.:..||.|..::|.
  Fly   353 KMTYMDMVISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPE 417

Human   494 PETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPL 558
            |..|:|:||:.|.:....|:||||||.|||:|:|.|..|::||..|.::|..::.:|.|.|...|
  Fly   418 PRKFDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDL 482

Human   559 QLESKSALG----PKNGVYIKIVSR 579
            .   .||.|    |::|.::.:|.|
  Fly   483 W---GSASGFNFTPRSGFWMHLVPR 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBXAS1NP_001159725.2 p450 47..576 CDD:306555 144/571 (25%)
Cyp9b2NP_523646.1 p450 37..478 CDD:299894 137/544 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 277 1.000 Inparanoid score I2940
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 1 1.000 - - FOG0000037
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.870

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