Protein Alignment TBXAS1 and Cyp6a16

DIOPT Version :9

• Sequence 1: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_001285631.1
• Gene: Cyp6a16 / 19836250
• FlyBaseID: FBgn0031726
• Length: 500
• Species: Drosophila melanogaster
• Alignment Length: 586
• Identity: 161/586 - (27%)
• Similarity: 268/586 - (45%)
• Gaps: 123/586 - (20%)

Human    17 TVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR-QGFWESQMELRKLY------ 74
            |:.|..:||:.|..|....|:..|..|:...:|....|:  ||| |....|:: |::.|
  Fly     4 TLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGH--FFRLQSVHYSEL-LQETYDAFRGS 65

Human    75 GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGAL 139
            ..:.|.|:..|...|:.:.|::|.||:.:|:||.:|.:  .....:..::..|:.:.|..:|..|
  Fly    66 AKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRS--FHGDPLTANLFNLQGEEWRNLRTKL 128

Human   140 MSAFSPEKLNEL-GLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPLISQ 203
            ...|:..|:..: |.:   ..:...:||..       ..|....|..:.||
  Fly   129 SPTFTSGKMKYMFGTV---STVAQQLGGTF-------DELVGSQGAVLELH-------------- 169

Human   204 ACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIP 268
              ||:                    ..|||||:.|.||||...|.:.|:..|.:..:|.|... .
  Fly   170 --DLM--------------------ARYTTDVIGSCAFGTECSSLREPQAEFRQVGRRIFRNS-N 211

Human   269 RPI------LVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQM 327
            |.|      :..|.|...:.:|: |||    ..::..|||:::|..:.||:::  ..||.||:.:
  Fly   212 RSIRWRIFKMTYLSSLAKLGLPV-RIL----HPDITKFFNRIVRETVELRERE--NIRRNDFMDL 269

Human   328 VLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEII 392
            :||.|...:..|                                ||::::..|||:|.:||:|..
  Fly   270 LLDLRRQENGKG--------------------------------LTMEQMAAQAFVFFVAGFETS 302

Human   393 TNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFT 457
            ::.:|:|.:.||.|.|.|:||..|::....||....:.::.| :||||..|.||||.||.....|
  Fly   303 SSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMME-MPYLDQTITETLRKYPALSSLT 366

Human   458 REAAQDCEVLGQRIPA-----------GAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHR 511
            |.|::|.|     ||:           |..:.:.|.|:|:|||.:|.|..|.||||..:|.::..
  Fly   367 RLASEDYE-----IPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERH 426

Human   512 PFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKS-ALGPKNGVYIK 575
            |..:|.||.|||:|:|:|.|.::||:.|:.:|.:|||...|.:...|::..:: .|.|.:||.::
  Fly   427 PTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQ 491

Human   576 I 576
            :
  Fly   492 V 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	152/554 (27%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	152/556 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820