DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBX6 and tbx6

DIOPT Version :9

Sequence 1:	NP_004599.2	Gene:	TBX6 / 6911	HGNCID:	11605	Length:	436	Species:	Homo sapiens
Sequence 2:	NP_001007995.1	Gene:	tbx6 / 493357	XenbaseID:	XB-GENE-6257419	Length:	517	Species:	Xenopus tropicalis

Alignment Length:	486	Identity:	223/486 - (45%)
Similarity:	276/486 - (56%)	Gaps:	89/486 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     1 MYHPRELYPSLGAGYRLGPAQPGADSSFPPALA----------EGYRYPELDTP--KLDCFLSGM 53
            ||| .||:...|..|.:.|         |.|||          |.|||||||.|  :.|.....:
Frog     1 MYH-SELFQQYGTSYGMRP---------PHALAPTYPTAGGHHEAYRYPELDVPGQRFDGLFPAL 55

Human    54 EAAPRTLAAHP--PLPLLP-PAMG---TEPAPSAPEALHSLPG-VSLSLENRELWKEFSSVGTEM 111
            :.:.|.|.|.|  ||.|.| ||:|   .:|....|:    ||| |.::|||:||||:|.|:||||
Frog    56 DPSQRILGAPPLTPLSLPPGPALGFGQLQPPCETPQ----LPGNVKMNLENKELWKQFHSIGTEM 116

Human   112 IITKAGRRMFPACRVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHP 176
            ||||:||||||.|:||||||:|:.:||.|.|::|:|.:||:||..||||||:||||||:||||||
Frog   117 IITKSGRRMFPQCKVSVTGLEPDGKYLLLADIVPIDNSRYKWQEDRWEPSGRAEPRLPERVYIHP 181

Human   177 DSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRF 241
            ||||.|:|||:||:|||::||||:|||..||:|||||||||||.|:|||..:.|:.|||.:||.|
Frog   182 DSPAPGSHWMKQPISFHKIKLTNNTLDQMGHIILHSMHKYQPRFHIVRAQDVFSRRWGGCSSFTF 246

Human   242 PETTFISVTAYQNPQITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATEAYGSGDT 306
            |||.|::||||||.:||||||..|||||||||:|...||:|..|||||:..||....|....|:.
Frog   247 PETLFLTVTAYQNEKITQLKIQTNPFAKGFREDGMKSKRDRSTRVKRKVIEPEEEEEEFQPEGEC 311

Human   307 P----GGPCDSTLGGDIRESDPEQAPAPGEATAAPAPLCGGPSAEAYLLHPAAFHGAPSHLP--- 364
            .    .|||||||.   .|.|..:    |.....|:|.|.        .||..   .||..|
Frog   312 KRPLYTGPCDSTLS---EELDIGR----GLGIPLPSPDCS--------FHPIT---PPSRTPPST 358

Human   365 -TRSPSFPEAPDSGRSAPYSA------------AFLELPHGSGGSGYPAA-----------PPAV 405
             |.:||.....:.|.:...|:            ::.|.|...|||.||..           |.:|
Frog   359 QTPNPSLTANQEQGAALEMSSQTPETFLQAAGQSYPEQPPVRGGSLYPCPTDGHGAQNQRHPLSV 423

Human   406 PFAPHFLQG-----GPFPLPYTAPGGYLDVG 431
            ...|...||     |..|..|...||  |||
Frog   424 QRLPQAFQGLQESLGNSPGEYKIYGG--DVG 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX6	NP_004599.2	TBOX	90..277	CDD:238106	131/187 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..339		27/71 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..379		7/22 (32%)
tbx6	NP_001007995.1	T-box	100..278	CDD:307177	126/177 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..318		16/41 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..418		21/95 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I9445
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I9554
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003805
OrthoInspector	1	1.000	-	-		otm55149
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6331
SonicParanoid	1	1.000	-	-		X4271
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.090