Protein Alignment TBX6 and bi

DIOPT Version :9

• Sequence 1: NP_004599.2
• Gene: TBX6 / 6911
• HGNCID: 11605
• Length: 436
• Species: Homo sapiens
• Sequence 2: NP_001259238.1
• Gene: bi / 31379
• FlyBaseID: FBgn0000179
• Length: 1023
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 172/502 - (34%)
• Similarity: 229/502 - (45%)
• Gaps: 118/502 - (23%)

Human     3 HPRELYPSLGAGYRLGPAQPGADSSFPPALAEGYRYPELDTPKLDCFLSGMEAAPRTLAAHPPLP 67
            || .|||  |.|.|..|..|||   .|.|...|..|    |...|..|:       :..||...|
  Fly   262 HP-GLYP--GGGLRFPPHHPGA---HPHAHHLGSAY----TTAEDVVLA-------SAVAHQLHP 309

Human    68 LLPPAMGTEPAPSAPEALHSLPGV----SLSLENRELWKEFSSVGTEMIITKAGRRMFPACRVSV 128
            .:.|....:|...         ||    .::||.::||::|..:||||:|||:||:|||..:..|
  Fly   310 AMRPLRALQPEDD---------GVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRV 365

Human   129 TGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFH 193
            :|||.:|:|:.|||::..|..||::...||..:|||:|.:|.|:|||||||.||..||::.||||
  Fly   366 SGLDAKAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFH 430

Human   194 RVKLTNSTLDPHGHL---ILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPETTFISVTAYQNP 255
            ::||||:..|.||.:   ||:||||||||.|||||..:....:....::.|.||.||:||||||.
  Fly   431 KLKLTNNISDKHGFVSTTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNE 495

Human   256 QITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATEAYGSGDTP------GGP---- 310
            :||||||..||||||||:.|...:.::.|.:..:....:........|...|      |.|
  Fly   496 KITQLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLH 560

Human   311 -----CDSTLGGDIRESD---PEQAP------------APGEATAAPA---PLCG-GPSAEAYLL 351
                 .|:....|.:..|   |.|:|            |...:.|..|   .|.| |..|..:..
  Fly   561 PHAALLDNQQDDDDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAA 625

Human   352 HPAAFHGAPSHL--------------------------------PTRSPSFPEAPDSGRSAPYSA 384
            ..||...|...|                                ||.:.|..||  .|.:|..:|
  Fly   626 AAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEA--VGAAAAAAA 688

Human   385 AFLELPHGSGGSGYPA-----APPAVPFAPHFLQGGPFPLPYTAPGG 426
            |.|    ..||..||:     .||..| :||.       |||..|.|
  Fly   689 AGL----NPGGGSYPSPNISVGPPIHP-SPHL-------LPYLYPHG 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX6	NP_004599.2	TBOX	90..277	CDD:238106	102/193 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..339		17/100 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..379		7/50 (14%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	23/72 (32%)
		T-box	330..513	CDD:279278	98/182 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810