Protein Alignment TBX5 and byn

DIOPT Version :10

• Sequence 1: XP_016875401.1
• Gene: TBX5 / 6910
• HGNCID: 11604
• Length: 534
• Species: Homo sapiens
• Sequence 2: NP_524031.2
• Gene: byn / 39349
• FlyBaseID: FBgn0011723
• Length: 697
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 162/507 - (31%)
• Similarity: 231/507 - (45%)
• Gaps: 98/507 - (19%)

Human    70 IKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFAD 134
            :::.|.:|||||:|..:..|||:||.||||||..|:..:||:|...|.:|::.|..|.||:|:.:
  Fly    87 LRISLDDRELWLRFQNLTNEMIVTKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVN 151

Human   135 NKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRL 199
            .:|...||||......:||||:||..|||||::.:||.|:||||. .:..|.|:|||:|||:||:
  Fly   152 GEWVPGGKAEVPPSNPIYVHPESPNFGAHWMKEPISFAKVKLTNK-TNGNGQIMLNSLHKYEPRV 215

Human   200 HIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMS 264
            |:|:.      ||:.....|:.||||.|||||:|||.::|.|||:.|||||.|
  Fly   216 HLVRV------GSEQRHVVTYPFPETQFIAVTAYQNEEVTSLKIKYNPFAKAF------------ 262

Human   265 RMQSKEYP------------VVPRST------------VRQKVASNHS-----PFSSESRALSTS 300
             :.:||.|            ::|..|            ....:|.:|.     |..|.:.::..|
  Fly   263 -LDAKERPDTLYPHDTHYGWLIPPPTHYTAAAAAVAAPPPLSIAQSHGLVASCPSVSSAESVGPS 326

Human   301 SNLGSQYQCEN-GVSGPSQDLLPP-PNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETS- 362
            |. ||   |:. |.|..|:.:.|. ..||..|:..|. ...........||:..|...|...||
  Fly   327 SG-GS---CDRYGRSLSSRSVAPTRTTPYSRPRVVSG-SGSNGSAGNASSTSPQPPSAPQTPTSL 386

Human   363 PSEEDSFYRSSYPQQQGLGASYRTESAQRQACM---YASS------APPSEPVPSLEDISCNTWP 418
            .|.......:|.....|.|..    ||....|.   ||.|      |.|:..|.|..    ::|.
  Fly   387 HSTSTGSVSTSVSSSSGGGIG----SAPSTGCFSSSYAQSGFMSVDASPTASVFSYP----SSWQ 443

Human   419 SMPSYSSCT-VTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEG----MFQHQTSVA 478
            |..:|.:.| |....||:....::.|:|.:..|         .:|||.....    ...|.|..:
  Fly   444 SNGNYWNATSVPGPMPMNVCSGRNISSHNSPSP---------TNGSPSYTTSSPSYTIHHLTPHS 499

Human   479 HQPVVRQC---GPQTGL-QSPGTLQPPEFLY---SHGV--PRTLSP-HQYHS 520
            ||..:.|.   |...|: ...||...|:..|   :|.|  |...|| ||.::
  Fly   500 HQYNMAQTDIYGTGVGVGGGAGTTGSPQAAYGAAAHQVYHPTPTSPTHQLYT 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX5	XP_016875401.1	T-box_TBX4_5-like	70..254	CDD:410315	89/183 (49%)
byn	NP_524031.2	T-box_TBXT_TBX19-like	87..264	CDD:410318	89/196 (45%)