Protein Alignment TBX5 and Doc2

DIOPT Version :9

• Sequence 1: XP_016875401.1
• Gene: TBX5 / 6910
• HGNCID: 11604
• Length: 534
• Species: Homo sapiens
• Sequence 2: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Alignment Length: 434
• Identity: 152/434 - (35%)
• Similarity: 207/434 - (47%)
• Gaps: 102/434 - (23%)

Human    67 MEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYK 131
            :.|:::.|...:||.:||::||||||||:|||||||.::.|:||..::.|.:|:::||..|.|||
  Fly    53 LPGVEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRYK 117

Human   132 FADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQ 196
            |:.::|...|.|||..|.|:|:|||||||||||..|.:.|.|:|||||.||..|||:|.||||||
  Fly   118 FSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLASMHKYQ 182

Human   197 PRLHIVK-ADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFR------- 253
            ||||::: ||......:...||   ||.||.|:|||:|||.:||:|||:|||||||||
  Fly   183 PRLHVIRTADLAQIPWAPQQAF---VFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRC 244

Human   254 ---------GSDDMELHRMSRMQSK-EYPVVP----------RSTVRQKVASNHSPFSSESRALS 298
                     |.|..:...:|..||: |..:.|          .|::............|...|.|
  Fly   245 KRKMSSSPTGEDQDQSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQIKRLRSNGSACS 309

Human   299 TSSNLGSQYQCENGVSGPSQDLL--PPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMET 361
            .||:|..|     .|.|.|...|  |||:.:    .||                 ||:  |....
  Fly   310 LSSSLDDQ-----SVPGASSLALGSPPPHLH----SHS-----------------HPH--PLQAR 346

Human   362 SPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSC 426
            |.|   |.:...:  ||.:.:..|                     |||.|::|..:.....|..
  Fly   347 SAS---SVFMQHF--QQNMQSLLR---------------------PSLVDLACTYFGRPHEYGG- 384

Human   427 TVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGM 470
               .:|.....|           |.....||:..|....|..|:
  Fly   385 ---AIQASPMYP-----------PAAMLQAGLGPHPGLNLPPGV 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX5	XP_016875401.1	TBOX	69..257	CDD:238106	106/204 (52%)
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	105/189 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910