Protein Alignment TBX5 and Doc3

DIOPT Version :10

• Sequence 1: XP_016875401.1
• Gene: TBX5 / 6910
• HGNCID: 11604
• Length: 534
• Species: Homo sapiens
• Sequence 2: NP_648280.1
• Gene: Doc3 / 39036
• FlyBaseID: FBgn0035954
• Length: 424
• Species: Drosophila melanogaster
• Alignment Length: 423
• Identity: 146/423 - (34%)
• Similarity: 201/423 - (47%)
• Gaps: 99/423 - (23%)

Human    55 PSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILL 119
            |..||.  |..|  .::..|...|||.:||.:||||||||.|||||||.:|.::||..:..|.:|
  Fly    48 PPPPQP--TLPG--DVEAKLENNELWQQFHSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVL 108

Human   120 MDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPF 184
            :::||..|.||||:.::|...|.|||..|.|:|:||:|||||.||..|.:.|.|:|||||.||..
  Fly   109 LEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNN 173

Human   185 GHIILNSMHKYQPRLHIVKADENNGFG----SKNTAFCTHVFPETAFIAVTSYQNHKITQLKIEN 245
            |||:|.||||||||||:::..:   .|    :...||   :||||.|||||:|||.:||:|||:|
  Fly   174 GHIVLASMHKYQPRLHVIRTSD---LGQIPWAPQQAF---IFPETEFIAVTAYQNDRITKLKIDN 232

Human   246 NPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCE 310
            ||||||||.|.                   :|..::|:..:..|...|:..:..|.
  Fly   233 NPFAKGFRESG-------------------QSRCKRKINDSPPPTQPEANQVDRSP--------- 269

Human   311 NGVSGPSQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYM---------------- 359
              |:.|....|.....:| ...|.|.:|..            |.::.|:
  Fly   270 --VTSPLAKRLRLVEEFP-QHHHHQSHHSV------------PMQRHYLLDALEANFYVPAPPPP 319

Human   360 ----------------ETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACM------YASSAPP 402
                            .|.||...|...||.....|..|:.|...|.....:      .|:..||
  Fly   320 AIEYARHIGGAYPSWAYTPPSPASSVSSSSAGSTSGESAADREADADADTFVDVVGTAPAAPPPP 384

Human   403 SEPVP--SLEDISCNTWPSM--PSYSSCTVTTV 431
            |.|||  :....|.::.|:|  |..||.:::.:
  Fly   385 SPPVPATATAPASSSSDPTMAKPKRSSFSISDI 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX5	XP_016875401.1	T-box_TBX4_5-like	70..254	CDD:410315	102/187 (55%)
Doc3	NP_648280.1	T-box_Drosocross-like	59..241	CDD:410332	102/187 (55%)