Protein Alignment TBX5 and mid

DIOPT Version :10

• Sequence 1: XP_016875401.1
• Gene: TBX5 / 6910
• HGNCID: 11604
• Length: 534
• Species: Homo sapiens
• Sequence 2: NP_608927.2
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Alignment Length: 498
• Identity: 160/498 - (32%)
• Similarity: 228/498 - (45%)
• Gaps: 99/498 - (19%)

Human     8 ARAQGPGRTMADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKV 72
            |.|:....|.:.:.:| ..:..|..|..:|......||....||....|.     ....::.::.
  Fly   130 ASAESQLNTSSTSSQG-RCSTPPQSPGTEDSEERLTPEPVQKAPKIVGSC-----NCDDLKPVQC 188

Human    73 FLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTG----LNPKTKYILLMDIVPADDHRYKFA 133
            .|..:|||.:||::||||||||.||||||:.:|..:|    :.|..:|.:||||:|.|..||::|
  Fly   189 HLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYA 253

Human   134 DNK--WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQ 196
            .::  |.|.|||:||.|.|||.|||||.:.....:|::||:|:|||||.:|..|.|:|||||:||
  Fly   254 YHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQ 318

Human   197 PRLHIVKADENNGFGS-----KNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGS- 255
            ||:|:|:........|     ::....|:|||||.|.|||:|||..||:|||::||||||||.|
  Fly   319 PRIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSS 383

Human   256 -------DDME---LHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSN-------- 302
                   |.||   |.:..|...:.:|    ..:.|:.|:...|   .|.||...:.
  Fly   384 RLTDFDRDPMEALLLEQQLRSPLRLFP----DPLMQQFAAQGDP---SSMALFEKARQHLQMFGG 441

Human   303 --------LGSQYQCENGVSGPSQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYM 359
                    :...||.....:||     |||.|      ....:|.                  :.
  Fly   442 NSPYAQLMMPQMYQAAAAAAGP-----PPPPP------GLGAFHM------------------FQ 477

Human   360 ETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQ---ACMYASSAPPSEPVPSLEDISCNTWPSMP 421
            :..|.....|..|:..|.....|:.:.: ||.|   |.|.|:..||..|..|....:.:..||
  Fly   478 QQWPQLTAGFLASANQQAAAAQAAAQAQ-AQAQAAAAAMAANRTPPPPPTASTPSSTSSGSPS-- 539

Human   422 SYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSP 464
                   ..::|..   ||.||.:...|...|..:..   |||
  Fly   540 -------PDMRPRQ---YQRFSPYQLPGGQGPPSSAA---GSP 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX5	XP_016875401.1	T-box_TBX4_5-like	70..254	CDD:410315	98/194 (51%)
mid	NP_608927.2	T-box_TBX20-like	186..382	CDD:410319	99/195 (51%)