Protein Alignment TBX5 and H15

DIOPT Version :9

• Sequence 1: XP_016875401.1
• Gene: TBX5 / 6910
• HGNCID: 11604
• Length: 534
• Species: Homo sapiens
• Sequence 2: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Alignment Length: 471
• Identity: 152/471 - (32%)
• Similarity: 222/471 - (47%)
• Gaps: 74/471 - (15%)

Human    14 GRTMADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPS---SPQ--AAFTQQGMEGIKVF 73
            ||:.|    ..|.|.||..|...  |..|..|....:|.:||:   :|:  .:.....:..::..
  Fly   222 GRSAA----AVGAAATPSPPPPP--PSQSPEELERLSPEESPAQQPTPKIVGSCNCDDLTPVQCH 280

Human    74 LHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTG----LNPKTKYILLMDIVPADDHRYKFAD 134
            |..:|||.||||:||||||||:||||||:.:|..:|    :.|..:|.:|:|:||.|..||::|.
  Fly   281 LETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYRYAY 345

Human   135 NK--WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQP 197
            ::  |.|.|||:|..|.|:|.|||.|.:.....:|:|||:|:|||||.:|..|.::|||||:|||
  Fly   346 HRSSWLVAGKADPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQP 410

Human   198 RLHIVKADENNGF-GS----KNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDD 257
            |:|:|:....... ||    ::....|.|||||.|.|||:|||..||:|||::||||||||.|..
  Fly   411 RIHLVRLSHGQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSR 475

Human   258 MELHRMSRMQS----KEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGPSQ 318
            :.......|.:    :.....|.......:.|..:|..:::.:::.........|. .|.|..::
  Fly   476 LSDFDRDPMDAFFFDQHMRTAPLRFFPDPLMSQLTPQEADAASMALLEKARQHLQM-FGRSPYTE 539

Human   319 DLLP--------PPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYP 375
            .|||        ||.|.|.|  |...:..                            ..::..:|
  Fly   540 MLLPHLYQRSAAPPPPPPAP--HLSAFQL----------------------------GMWQQQWP 574

Human   376 Q-QQGLGASYRTESAQRQACMYASSAPP-----SEPVPSLEDISCNTWPSMPSYSSCTVTTVQPM 434
            | ..|..||...::|...|...|:..||     :.|.|:....||.:  :.|...:.......|.
  Fly   575 QLTAGFLASANQQAALALAAAGANRTPPPSMAVAPPAPATPTSSCGS--ASPDLRARPQLNHYPQ 637

Human   435 DRLPYQHFSAHFTSGP 450
            ...||| ...|..|.|
  Fly   638 RFSPYQ-VPQHQASPP 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX5	XP_016875401.1	TBOX	69..257	CDD:238106	99/198 (50%)
H15	NP_608926.2	TBOX	276..475	CDD:238106	99/198 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740