Protein Alignment TBX5 and bi

DIOPT Version :9

• Sequence 1: XP_016875401.1
• Gene: TBX5 / 6910
• HGNCID: 11604
• Length: 534
• Species: Homo sapiens
• Sequence 2: NP_001259238.1
• Gene: bi / 31379
• FlyBaseID: FBgn0000179
• Length: 1023
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 184/548 - (33%)
• Similarity: 250/548 - (45%)
• Gaps: 135/548 - (24%)

Human    44 PESALGAPSKSPSSPQ--------------------------AAFT------------------- 63
            |.:||.|.:.||:.|.                          :|:|
  Fly   247 PAAALAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAM 311

Human    64 ------QQGMEGI----KVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYIL 118
                  |...:|:    ||.|..::||.|||::||||:|||:||:|||..|.:|:||:.|.||||
  Fly   312 RPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYIL 376

Human   119 LMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDP 183
            |:|||.|||:||||.:::|.|.|||:|.||.|:|:|||||.||..||:::|||.|||||||..|.
  Fly   377 LLDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDK 441

Human   184 FGHI---ILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIEN 245
            .|.:   |||||||||||.|:|:|  |:......:.|.|:||.||.|||||:|||.|||||||:|
  Fly   442 HGFVSTTILNSMHKYQPRFHLVRA--NDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDN 504

Human   246 NPFAKGFR----GSDDMELHRMSRMQSKEYPVVPR--STVRQKVASNHS---PFSSESRALSTSS 301
            ||||||||    |..:.:...||...|....:.|.  |:.|..:...|:   |......||
  Fly   505 NPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAAL---- 565

Human   302 NLGSQYQCENGVSGPSQDLLPPPNPYPLPQEHS-QIYHCTKRKEEECSTTDH--------PYKKP 357
             |.:|...::.:    .|::.||....||..|| |..|..:......:..:|        .....
  Fly   566 -LDNQQDDDDKL----LDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAA 625

Human   358 YMETSPSEEDSFYR--------------SSYPQQQG--LGASYRTESAQRQACMYASSAPPSEPV 406
            ....:.|.||:..|              ||..:..|  .|.::|.          .|:..|.|.|
  Fly   626 AAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRP----------TSTGSPKEAV 680

Human   407 -PSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGM 470
             .:....:....|...||.|..::...|:      |.|.|     |:|.|.....:..|.||
  Fly   681 GAAAAAAAAGLNPGGGSYPSPNISVGPPI------HPSPH-----LLPYLYPHGLYPPPHLG--- 731

Human   471 FQHQTSVAHQPVVRQCGPQTGLQSPGTL 498
                  :.|.|.........|| :||.|
  Fly   732 ------LLHNPAAAAAMSPAGL-NPGLL 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX5	XP_016875401.1	TBOX	69..257	CDD:238106	118/198 (60%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	3/57 (5%)
		T-box	330..513	CDD:279278	114/184 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810