DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBX2 and Doc1

DIOPT Version :9

Sequence 1:	NP_005985.3	Gene:	TBX2 / 6909	HGNCID:	11597	Length:	712	Species:	Homo sapiens
Sequence 2:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster

Alignment Length:	336	Identity:	150/336 - (44%)
Similarity:	198/336 - (58%)	Gaps:	59/336 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   109 LEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWM 173
            ||..:||.||||:||||:||||||||||..:|.:|||:::|.|.:|:::|...||||||..|:|:
  Fly    63 LENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWV 127

Human   174 VAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVR 238
            .||.|:|:.|:|||:||||||||..|.::.:.|:|:|||||..|..|..:|.||||||||.||:|
  Fly   128 PAGGAEPQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDSSGHIVLASMHKYQPRLHIIR 192

Human   239 ANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRK-----Q 298
            ::::.:||::..:.:|||||:|:||||||||:||:|||||||||||||::|..|. |||     .
  Fly   193 SSELTQLPWAPQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRESGQSRC-KRKLNSSGN 256

Human   299 LTLPSLRLYEEHCKPERDGAESDASSCDPP------------------PAREPPTSPGAAP-SP- 343
            .||.|          |.||  |..||||.|                  ||....|.|.|.| ||
  Fly   257 STLES----------EDDG--SSVSSCDSPQAKRQRQDFEQDSTGSVSPAYYGATHPVANPMSPY 309

Human   344 LRLHRARAEEKSCAADSDPE----------PERLSEERAG--------APLGRSPAPDSASPTRL 390
            ||.|.:..  .|.||...|.          |:.|....|.        :|:...|. .|::||..
  Fly   310 LRHHLSYG--PSGAAGLPPSIAAAYFGGVPPQILPMPPATYAPTVAPVSPVASQPV-GSSTPTTS 371

Human   391 TEPERARERRS 401
            ..|..:.:|.|
  Fly   372 PRPSTSTKRNS 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	106/177 (60%)
		PHA03307	300..>467	CDD:223039	38/140 (27%)
		TBX	305..383	CDD:403708	29/115 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..450		35/127 (28%)
		Repression domain 1 (RD1)	518..601
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..687
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	108/181 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840