Protein Alignment TBX2 and Doc3

DIOPT Version :10

• Sequence 1: NP_005985.3
• Gene: TBX2 / 6909
• HGNCID: 11597
• Length: 712
• Species: Homo sapiens
• Sequence 2: NP_648280.1
• Gene: Doc3 / 39036
• FlyBaseID: FBgn0035954
• Length: 424
• Species: Drosophila melanogaster
• Alignment Length: 405
• Identity: 153/405 - (37%)
• Similarity: 217/405 - (53%)
• Gaps: 78/405 - (19%)

Human    52 LPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWD 116
            |||| |.|.....|.         |.  :.|.||           |:..:..|.:..||..|||.
  Fly    29 LPDP-LCGLLPNFAG---------HF--MPPPPP-----------PQPTLPGDVEAKLENNELWQ 70

Human   117 QFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPE 181
            |||.:||||:|||.||||||..:|.:|||:::|.|.:|:::|...||||||..|:|:.||.|:|:
  Fly    71 QFHSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQ 135

Human   182 MPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLP 246
            .|:|||:||:|||||:.|.::.:.|.|:|||||..|.:|..:|.||||||||.|::|.:|:.::|
  Fly   136 SPQRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNNGHIVLASMHKYQPRLHVIRTSDLGQIP 200

Human   247 YSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREK---------------- 295
            ::..:.::||||:||||||||||:||:|||||||||||||::|..|.::
  Fly   201 WAPQQAFIFPETEFIAVTAYQNDRITKLKIDNNPFAKGFRESGQSRCKRKINDSPPPTQPEANQV 265

Human   296 -RKQLTLP---SLRLYEE----------HCKPERDGAESDASSCD------PPPARE-------- 332
             |..:|.|   .|||.||          |..|.:.....||...:      ||||.|
  Fly   266 DRSPVTSPLAKRLRLVEEFPQHHHHQSHHSVPMQRHYLLDALEANFYVPAPPPPAIEYARHIGGA 330

Human   333 ------PPTSPGAAPSPLRLHRARAE---EKSCAADSDPEPERLSEERAGAPLGRSPAPDSAS-- 386
                  .|.||.::.|.........|   ::...||:|...:.:....|..|....|.|.:|:
  Fly   331 YPSWAYTPPSPASSVSSSSAGSTSGESAADREADADADTFVDVVGTAPAAPPPPSPPVPATATAP 395

Human   387 PTRLTEPERARERRS 401
            .:..::|..|:.:||
  Fly   396 ASSSSDPTMAKPKRS 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	104/183 (57%)
		PHA03307	300..>467	CDD:223039	33/140 (24%)
		TBX	305..383	CDD:432659	24/110 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..450		25/114 (22%)
		Repression domain 1 (RD1). /evidence=ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:30599067	518..601
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..687
Doc3	NP_648280.1	T-box_Drosocross-like	59..241	CDD:410332	103/181 (57%)