DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBX2 and H15

DIOPT Version :10

Sequence 1:NP_005985.3 Gene:TBX2 / 6909 HGNCID:11597 Length:712 Species:Homo sapiens
Sequence 2:NP_608926.2 Gene:H15 / 33769 FlyBaseID:FBgn0016660 Length:660 Species:Drosophila melanogaster


Alignment Length:619 Identity:186/619 - (30%)
Similarity:246/619 - (39%) Gaps:227/619 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    59 GAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDE--VEDDPKVT------------- 108
            |.:|||..|||....       .|.||:.....|:.|.||:.  .:..||:.             
  Fly   222 GRSAAAVGAAATPSP-------PPPPPSQSPEELERLSPEESPAQQPTPKIVGSCNCDDLTPVQC 279

Human   109 -LEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSG----LDKKAKYILLMDIVAADDCRYK-- 166
             ||.|||||:||:|||||:||||||||||..:|..||    :....:|.:|:|:|..|..||:  
  Fly   280 HLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYRYA 344

Human   167 FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQ 231
            :|.|.|:|||||||..|.|:|.|||.|.:.|....:.|:|.|:|||||..||.|..:|||||:||
  Fly   345 YHRSSWLVAGKADPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQ 409

Human   232 PRFHIVRANDILKLPYS-------TFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTG 289
            ||.|:||.:....:|.|       ..:|:|||||.|.|||||||..||:||||:|||||||||:.
  Fly   410 PRIHLVRLSHGQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSS 474

Human   290 NGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRLHRARAEEK 354
            ......|..:   ....:::|.:                            .:|||..       
  Fly   475 RLSDFDRDPM---DAFFFDQHMR----------------------------TAPLRFF------- 501

Human   355 SCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRLTEPERARERRSPERGKEPAESGGDGPFGL 419
                 .||...:|:.:.|          |:||...|            |:.::..:..|..|:  
  Fly   502 -----PDPLMSQLTPQEA----------DAASMALL------------EKARQHLQMFGRSPY-- 537

Human   420 RSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSA--SPLGAGHLPGLAFSSHLHGQQFFGP 482
                                    .:.|.|.:.|..:|  .|..|.||.  ||...:..||:   
  Fly   538 ------------------------TEMLLPHLYQRSAAPPPPPPAPHLS--AFQLGMWQQQW--- 573

Human   483 LGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTA 547
                                                       |...||.       .|||...|
  Fly   574 -------------------------------------------PQLTAGF-------LASANQQA 588

Human   548 APFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSL----SR 608
            |                               :|.|||.|:..|..|.|.|..|.|...    |.
  Fly   589 A-------------------------------LALAAAGANRTPPPSMAVAPPAPATPTSSCGSA 622

Human   609 SPFLGSARPRL-----RFSPYQIP--VTIPPSTS 635
            ||.| .|||:|     ||||||:|  ...||:::
  Fly   623 SPDL-RARPQLNHYPQRFSPYQVPQHQASPPASN 655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBX2NP_005985.3 T-box_TBX2_3-like 103..287 CDD:410314 106/210 (50%)
PHA03307 300..>467 CDD:223039 23/168 (14%)
TBX 305..383 CDD:432659 8/77 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..450 15/136 (11%)
Repression domain 1 (RD1). /evidence=ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:30599067 518..601 17/82 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..687
H15NP_608926.2 T-box_TBX20-like 277..473 CDD:410319 105/195 (54%)
Blue background indicates that the domain is not in the aligned region.

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