Protein Alignment TBX2 and Tbx2

DIOPT Version :10

• Sequence 1: NP_005985.3
• Gene: TBX2 / 6909
• HGNCID: 11597
• Length: 712
• Species: Homo sapiens
• Sequence 2: NP_001388735.1
• Gene: Tbx2 / 303398
• RGDID: 1311014
• Length: 711
• Species: Rattus norvegicus
• Alignment Length: 714
• Identity: 680/714 - (95%)
• Similarity: 686/714 - (96%)
• Gaps: 5/714 - (0%)

Human     1 MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAA 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAA 65

Human    66 AAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKS 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 AAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKS 130

Human   131 GRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 GRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 195

Human   196 GEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDF 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 GEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDF 260

Human   261 IAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSC 325
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
  Rat   261 IAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSC 325

Human   326 DPPPAREPPTSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRL 390
            |||||||||.||.||||||||||||||||.|||||||||||..||||.||||||.:.| |||.||
  Rat   326 DPPPAREPPPSPSAAPSPLRLHRARAEEKPCAADSDPEPERSGEERAAAPLGRSSSRD-ASPARL 389

Human   391 TEPERARERRSPERG-KEPAESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQT 454
            |||||:||||||||| |||.|.||||||.|||||||||||||||||||:..||||..||||||||
  Rat   390 TEPERSRERRSPERGSKEPTEGGGDGPFSLRSLEKERAEARRKDEGRKDVGEGKEPSLAPLVVQT 454

Human   455 DSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASVA-GG 518
            ||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||| ||
  Rat   455 DSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGG 519

Human   519 GNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAA 583
            ||.||..||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
  Rat   520 GNSGGAAPGTAAGLDAGGLGPAASAASTATPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAA 584

Human   584 AAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKA 648
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|.||
  Rat   585 AAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLAAESSK- 648

Human   649 AGGNSREPSPLPELALRKVGAPSRGALSPSGSAKEAANELQSIQRLVSGLESQRALSPGRESPK 712
             |||||||||||||||||||.||||||||||||||||:||||||||||||||||||||||||||
  Rat   649 -GGNSREPSPLPELALRKVGGPSRGALSPSGSAKEAASELQSIQRLVSGLESQRALSPGRESPK 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	183/183 (100%)
		PHA03307	300..>467	CDD:223039	145/167 (87%)
		TBX	305..383	CDD:432659	69/77 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..450		116/137 (85%)
		Repression domain 1 (RD1). /evidence=ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:30599067	518..601		78/82 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..687		44/49 (90%)
Tbx2	NP_001388735.1	T-box_TBX2_3-like	103..287	CDD:410314	183/183 (100%)
		TBX	305..379	CDD:432659	67/73 (92%)