Protein Alignment TBX2 and tbx2b

DIOPT Version :10

• Sequence 1: NP_005985.3
• Gene: TBX2 / 6909
• HGNCID: 11597
• Length: 712
• Species: Homo sapiens
• Sequence 2: NP_571126.1
• Gene: tbx2b / 30253
• ZFINID: ZDB-GENE-990726-27
• Length: 687
• Species: Danio rerio
• Alignment Length: 728
• Identity: 498/728 - (68%)
• Similarity: 556/728 - (76%)
• Gaps: 57/728 - (7%)

Human     1 MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAA 65
            ||:|....:|||||||||.||.|||||||||||||||||||.||||||.||:||..|||
Zfish     1 MRDPVFTGTAMAYHPFHAHRPTDFPMSAFLAAAQPSFFPALTLPPGALTKPIPDHTLAG------ 59

Human    66 AAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKS 130
                ||||||| .||..|..|||||||||||||:|||||||||||||:|||||||||||||||||
Zfish    60 ----AAEAGLH-PALSHHHQAAHLRSLKSLEPEEEVEDDPKVTLEAKDLWDQFHKLGTEMVITKS 119

Human   131 GRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 195
            |||||||||||::||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   120 GRRMFPPFKVRINGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 184

Human   196 GEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDF 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   185 GEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDF 249

Human   261 IAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSC 325
            |||||||||||||||||||||||||||||||||||||||||||||:||:.||.:||||:|||||.
Zfish   250 IAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRMYEDQCKVDRDGADSDASSS 314

Human   326 DPPPAREPPTSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRL 390
            :|...|:...|||...||||.:|...::|:| .||:.|.:..::...|:   .||||..:||.|.
Zfish   315 EPTTGRDAGHSPGPVSSPLRFNRGSRDDKTC-TDSEHEMDHQNDRCGGS---SSPAPKPSSPFRS 375

Human   391 TEPERARERRSPERGKEPAES--GGDGPFGLRSLEKERAEAR-RKD-EGRKEAAE-----GKEQG 446
            ...:..||:...|:..:..:|  ..|..|.:|:|||::.|:| ||| :..|:..|     |.:..
Zfish   376 RSEDWGREKPIAEKKDDYPDSRKTSDSIFSIRNLEKDKLESRSRKDTDSSKKDTENSGISGSKDS 440

Human   447 LAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGMGHL 511
            .:||:|||:|.|..|||||..||.|. ||.||||.||..||||..|||||.|.||||||||||||
Zfish   441 FSPLMVQTESPSHFGAGHLQSLALSG-LHSQQFFNPLNTGQPLLFHPGQFAMAPGAFSAMGMGHL 504

Human   512 LASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYP 576
            ||||:|.|           ||:.|.|. |....||.:||||||||||||||||||||||||||||
Zfish   505 LASVSGAG-----------GLENGSLS-AQGTGSTPSPFPFHLSQHMLASQGIPMPTFGGLFPYP 557

Human   577 YTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSA-RPRLRFSPYQIPVTIPPSTSLLTTG 640
            ||||||||||||||||:|:.|:      ||||:|||.|: ||||||:|||:||:||.||:|||||
Zfish   558 YTYMAAAAAAASALPASSSTAS------SLSRNPFLSSSTRPRLRFNPYQLPVSIPQSTNLLTTG 616

Human   641 L------ASEGSKAAGGNSREPSPLPELALRKVGAPSRGALSPSGSAKEAANELQSIQRLVSGLE 699
            |      :||.||.   .|||.||:|:   .|.||..|.. ||..:.||:.||||:|||||||||
Zfish   617 LPSGLNPSSESSKC---GSREASPVPD---HKSGASQRNG-SPKTTMKESINELQNIQRLVSGLE 674

Human   700 SQRALSPGRESPK 712
            |||..|..|:|||
Zfish   675 SQRETSSPRDSPK 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	180/183 (98%)
		PHA03307	300..>467	CDD:223039	72/175 (41%)
		TBX	305..383	CDD:432659	33/77 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..450		50/145 (34%)
		Repression domain 1 (RD1). /evidence=ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:30599067	518..601		54/82 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..687		23/55 (42%)
tbx2b	NP_571126.1	T-box_TBX2_3-like	95..276	CDD:410314	177/180 (98%)
		TBX	294..361	CDD:432659	29/67 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..452		56/152 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..687		43/82 (52%)