Protein Alignment TBX2 and Tbx2

DIOPT Version :10

• Sequence 1: NP_005985.3
• Gene: TBX2 / 6909
• HGNCID: 11597
• Length: 712
• Species: Homo sapiens
• Sequence 2: NP_033350.2
• Gene: Tbx2 / 21385
• MGIID: 98494
• Length: 711
• Species: Mus musculus
• Alignment Length: 714
• Identity: 678/714 - (94%)
• Similarity: 686/714 - (96%)
• Gaps: 5/714 - (0%)

Human     1 MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAA 65
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
Mouse     1 MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALGKPLPDPGLAGAAAAAA 65

Human    66 AAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKS 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 AAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKS 130

Human   131 GRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 GRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 195

Human   196 GEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDF 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 GEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDF 260

Human   261 IAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSC 325
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
Mouse   261 IAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSC 325

Human   326 DPPPAREPPTSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRL 390
            |||||||||.||.||||||||||||||||..||||||||||..|||:.|||||||:.| |||.||
Mouse   326 DPPPAREPPPSPSAAPSPLRLHRARAEEKPGAADSDPEPERTGEERSAAPLGRSPSRD-ASPARL 389

Human   391 TEPERARERRSPER-GKEPAESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQT 454
            |||||:|||||||| .|||.|.||||||.||||||||.||||||||||:..||||..||||||||
Mouse   390 TEPERSRERRSPERCSKEPTEGGGDGPFSLRSLEKERPEARRKDEGRKDVGEGKEPSLAPLVVQT 454

Human   455 DSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASVAGG- 518
            ||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
Mouse   455 DSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGS 519

Human   519 GNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAA 583
            |:.||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   520 GSSGGAGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAA 584

Human   584 AAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKA 648
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
Mouse   585 AAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLAAEGSK- 648

Human   649 AGGNSREPSPLPELALRKVGAPSRGALSPSGSAKEAANELQSIQRLVSGLESQRALSPGRESPK 712
             |||||||||||||||||||.||||||||||||||||:||||||||||||||||||||||||||
Mouse   649 -GGNSREPSPLPELALRKVGGPSRGALSPSGSAKEAASELQSIQRLVSGLESQRALSPGRESPK 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	183/183 (100%)
		PHA03307	300..>467	CDD:223039	142/167 (85%)
		TBX	305..383	CDD:432659	68/77 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..450		113/137 (82%)
		Repression domain 1 (RD1). /evidence=ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:30599067	518..601		79/83 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..687		45/49 (92%)
Tbx2	NP_033350.2	T-box_TBX2_3-like	103..287	CDD:410314	183/183 (100%)
		TBX	305..380	CDD:432659	66/74 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..449		112/136 (82%)
		Repression domain 1 (RD1). /evidence=ECO:0000250	518..602		79/83 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..687		43/48 (90%)