Protein Alignment TBP and Tbp

DIOPT Version :9

• Sequence 1: NP_003185.1
• Gene: TBP / 6908
• HGNCID: 11588
• Length: 339
• Species: Homo sapiens
• Sequence 2: NP_523805.1
• Gene: Tbp / 37476
• FlyBaseID: FBgn0003687
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 373
• Identity: 215/373 - (57%)
• Similarity: 235/373 - (63%)
• Gaps: 58/373 - (15%)

Human     1 MDQ----NNSLP----PYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQR 57
            |||    |.|:|    |..|..|..|....|  ....|.:.....|.|.|    .|.|:..:||:
  Fly     1 MDQMLSPNFSIPSIGTPLHQMEADQQIVANP--VYHPPAVSQPDSLMPAP----GSSSVQHQQQQ 59

Human    58 QQQ------------------QQQQQQQQQQQQQQQQQQQQQQQQQ---------QQQQQQQQQQ 95
            ||.                  .:|.|..|.....||||||||.|.|         |...|.|..|
  Fly    60 QQSDASGGSGLFGHEPSLPLAHKQMQSYQPSASYQQQQQQQQLQSQAPGGGGSTPQSMMQPQTPQ 124

Human    96 AVAAAAVQQSTSQQATQGTSGQAPQLFH-SQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESS 159
            ::.|..:..|.......|..|....|.: .||                |.|.||:|||||.|...
  Fly   125 SMMAHMMPMSERSVGGSGAGGGGDALSNIHQT----------------MGPSTPMTPATPGSADP 173

Human   160 GIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGA 224
            |||||||||||||||.||||||.|||.||||||||||||||||||||||||||||||||||||||
  Fly   174 GIVPQLQNIVSTVNLCCKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGA 238

Human   225 KSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFP 289
            |||:.||||||||||::||||||||||||||||||||||||||||||||||||..||||||||||
  Fly   239 KSEDDSRLAARKYARIIQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHCNFSSYEPELFP 303

Human   290 GLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRK 337
            ||||||::|||||||||||||||||||||.|||:||:.|:||||.|:|
  Fly   304 GLIYRMVRPRIVLLIFVSGKVVLTGAKVRQEIYDAFDKIFPILKKFKK 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBP	NP_003185.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		10/27 (37%)
		polyglutamine repeat	58..95		18/63 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..159		10/31 (32%)
		PLN00062	162..338	CDD:177693	158/176 (90%)
		Repetitive region	165..241		70/75 (93%)
		Repetitive region	255..332		67/76 (88%)
Tbp	NP_523805.1	PLN00062	176..351	CDD:177693	157/174 (90%)
		TBP_eukaryotes	176..349	CDD:239952	156/172 (91%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4353
eggNOG	1	0.900	-	-		E1_COG2101
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2225
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1219067at2759
OrthoFinder	1	1.000	-	-		FOG0001202
OrthoInspector	1	1.000	-	-		otm41205
orthoMCL	1	0.900	-	-		OOG6_100597
Panther	1	1.100	-	-	O	PTHR10126
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1482
SonicParanoid	1	1.000	-	-		X1201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860