Protein Alignment TBP and Trf5

DIOPT Version :10

• Sequence 1: NP_003185.1
• Gene: TBP / 6908
• HGNCID: 11588
• Length: 339
• Species: Homo sapiens
• Sequence 2: NP_608700.2
• Gene: Trf5 / 33454
• FlyBaseID: FBgn0031446
• Length: 305
• Species: Drosophila melanogaster
• Alignment Length: 243
• Identity: 46/243 - (18%)
• Similarity: 94/243 - (38%)
• Gaps: 12/243 - (4%)

Human    99 AAAVQQSTSQQATQGTSGQAPQLFHSQTLTTAPLPGTTPLYPSPMTPMTP-ITPATPASESSGIV 162
            |:..:::..:.|...||.|.|.  ..|.|......|...:....:.|..| :.......|:...:
  Fly    26 ASMSRKTLLEDAKLSTSDQDPS--DRQVLANKASEGAEEMSLPIVNPREPTLKDVLSIYENVSKL 88

Human   163 PQLQNIVSTV--NLGC------KLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKM 219
            ..:|..::.:  ...|      |..|..:.:..:|..:.|::..|:.:....|..:..|:..|.:
  Fly    89 GDIQRYLNVIYKPFYCLAMTTSKFHLLELDMGLKNTAFEPEKHMALFVYRYSPTRSIRIYPHGNI 153

Human   220 VCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYE 284
            .|. |..:..:|.......:.::.||:..:....|...:..:..|.|.:.|....|.:...:.|:
  Fly   154 YCQ-AFCKNSARYGLANILKELRYLGYAPRLRRLKTNAVNATFSVPFNLNLRQFHLENPVVTRYD 217

Human   285 PELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPIL 332
            ...:|.|:|:|:...:.:.||.:|.|::..|........|..:|.|.|
  Fly   218 TSKYPFLVYKMMGTTVEIAIFPTGYVIVLFATTMEITKLAIAHILPTL 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBP	NP_003185.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		polyglutamine repeat	58..95
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..159		5/32 (16%)
		PLN00062	162..338	CDD:177693	34/179 (19%)
		Repetitive region	165..241		13/83 (16%)
		Repetitive region	255..332		17/76 (22%)
Trf5	NP_608700.2	PLN00062	110..265	CDD:177693	31/155 (20%)
		TBP	189..268	CDD:425630	18/77 (23%)