Protein Alignment TBP and Trf4

DIOPT Version :10

• Sequence 1: NP_003185.1
• Gene: TBP / 6908
• HGNCID: 11588
• Length: 339
• Species: Homo sapiens
• Sequence 2: NP_608699.1
• Gene: Trf4 / 33452
• FlyBaseID: FBgn0031444
• Length: 331
• Species: Drosophila melanogaster
• Alignment Length: 261
• Identity: 54/261 - (20%)
• Similarity: 96/261 - (36%)
• Gaps: 42/261 - (16%)

Human   112 QGTSGQ---APQLFH----------SQTLTTAPLPGTTPLYPSPMTPMTPIT-PATPASE-SSGI 161
            :|||.:   ..:||.          .:.|.|.|:...:.||..... .:||. |...|.| .|.:
  Fly    31 EGTSAKLSSLDKLFEELKISKESSAKEDLVTEPMKTESYLYKDYFN-KSPIDFPWEKAYEKGSSL 94

Human   162 VPQL----QNIVSTV---------------------NLGCKLDLKTIALRARNAEYNPKRFAAVI 201
            .|..    :||...|                     :..|:..:..:.|....:.::|....:|:
  Fly    95 GPDFYIDYENIFDNVANLAEIEEKLELHFRPFTCVMDFNCRFSMYELCLLLAESRFDPSSHPSVV 159

Human   202 MRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKF 266
            ::|..|.....|.:.||:..| |.:.:.:|....|..|::|.|.:....::|....:..|..:.|
  Fly   160 VKITHPSAQVKIHAGGKISST-ALNADSARSGLFKVIRILQDLDYKVDIMNFSKNIVNASFSMPF 223

Human   267 PIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPI 331
            .|.|:.:...|....:......|.:.|......:...:|.:|.|::..:....|..||..|..||
  Fly   224 KIDLDLMSRRHVVEVAQNRSRRPFITYTTENLGVRFAVFPTGFVLVLHSTSHCETREAIANFLPI 288

Human   332 L 332
            |
  Fly   289 L 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBP	NP_003185.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		polyglutamine repeat	58..95
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..159		10/33 (30%)
		PLN00062	162..338	CDD:177693	38/196 (19%)
		Repetitive region	165..241		17/100 (17%)
		Repetitive region	255..332		15/76 (20%)
Trf4	NP_608699.1	TBP_TLF	131..>234	CDD:447593	21/103 (20%)
		TBP	213..292	CDD:425630	17/77 (22%)