DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERPINA7 and Spn88Eb

DIOPT Version :9

Sequence 1:	XP_006724746.1	Gene:	SERPINA7 / 6906	HGNCID:	11583	Length:	425	Species:	Homo sapiens
Sequence 2:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster

Alignment Length:	441	Identity:	109/441 - (24%)
Similarity:	190/441 - (43%)	Gaps:	75/441 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    27 VTACHSSQPNAT-LYKMSSI---NADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCS 87
            ||.....:|..: |.:.|.|   ..||:..|.::.....|..|:||||.|...||::..|.:...
  Fly    15 VTIAALDKPELSFLNEFSQIFKGERDFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQ 79

Human    88 TQTEIVETLGFN--------LTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLA 144
            |:.|:.:.|...        |....:.:.|..|:       :.:..:||...|.:|:.:.:....
  Fly    80 TERELAQALNLGWALNKQQVLVSYTLAQRQDEFR-------WRQSPMELSSANRIFVDRTINVSN 137

Human   145 KFLNDVKTLYETEVFSTDFSN-ISAAKQEINSHVEMQTKGKVVGLI--QDLKPNTIMVLVNYIHF 206
            ||    .||........||.| .....:|||..:..:|..::..::  :::.|:|::||.|..:.
  Fly   138 KF----NTLLYGATKELDFKNDPETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYM 198

Human   207 KAQWANPFDPSKTEDSS--SFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDY-------- 261
            |.||.:.|   |.|:::  .|.|::.....|.|||:...:...:|..|...::::.|
  Fly   199 KGQWLSQF---KVEETALKPFFINEREQEMVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKE 260

Human   262 -------SKNALA-LFVLPKEGQ--MESVEAAMSSKTLKKW--NRLLQKGWVDLFVPKFSISATY 314
                   ||:.:: :.:||...:  :..|.:.:::.::|||  ..|.||  ::|.:|||......
  Fly   261 THISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWFERALPQK--IELSLPKFQFEQRL 323

Human   315 DLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNRPAGFVLPTQAAHKAVLHIGEKGTEAAAVPE 379
            :|...|..||:...::.||.|..||.|        |...|: ..|.|.|.:.:.|.|:.|||...
  Fly   324 ELTPILSLMGVNTMFTRNATFGDLTAD--------PISLVI-DDAQHLAKIKVDEVGSTAAAATI 379

Human   380 V---ELSDQPENTFL---HPIIQIDRSFMLLILERSTRSILFLGKVVNPTE 424
            :   ..|.||:.|..   ||       |:.||.:....:|||.|...:|.:
  Fly   380 LLVSRSSRQPDPTKFNCNHP-------FVFLIYDEKVDTILFAGVYSDPRQ 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA7	XP_006724746.1	alpha-1-antitrypsin_like	46..419	CDD:239011	102/411 (25%)
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	102/412 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010