Protein Alignment TBCE and PAC2

DIOPT Version :10

• Sequence 1: NP_001274730.1
• Gene: TBCE / 6905
• HGNCID: 11582
• Length: 578
• Species: Homo sapiens
• Sequence 2: NP_010922.1
• Gene: PAC2 / 856724
• SGDID: S000000809
• Length: 518
• Species: Saccharomyces cerevisiae
• Alignment Length: 624
• Identity: 157/624 - (25%)
• Similarity: 263/624 - (42%)
• Gaps: 183/624 - (29%)

Human    10 IGRRVEVNGEHATVRFAGVVPPVAGPW-----LGVEWDNPERGKHDGSHEGTVYFKCRHPTGGSF 69
            ||.|:::.|...|::|.||:.    ||     .|||||:..||||.|:.:...||..:.|..|||
Yeast     5 IGDRLKIGGYFCTIKFIGVIK----PWPSVKAYGVEWDDHSRGKHSGTIDDIHYFDVQIPNSGSF 65

Human    70 IRPNKVNF----GTDFLTAIKNRYVLEDGPEEDRKEQIVTIGNKPVETIGFDSIMKQQSQLSKLQ 130
            ::.:|:..    ...|..|:..:|   .|...:..:  ::||||.||.:|||.:..:.....||:
Yeast    66 LKESKIKSPGVRRITFYEALSEKY---GGSSNNIND--LSIGNKRVEGLGFDELNARNKNYKKLR 125

Human   131 EVSLRNCAVSC----AGEKGGVAEACPNIRKVDLSKNLLSSWDEVIHIADQLRHLEVLNVSENKL 191
            :::||:..|:.    ..|...|.:.|.|::.:|||.||.::.:.:....:.|::||.||:|:|||
Yeast   126 KIALRDSDVAILFQNQDELNRVIQNCVNVKDLDLSLNLFTNINSLCEFIEPLKNLESLNISQNKL 190

Human   192 KFPSGSVLTGTLSVLKVLVLNQTGITWAEAHAQCGGSRHGLDMQKDASKFVDLCVLQKCSTSNCI 256
                   |:|                |                  |..|..||..::....|:|.
Yeast   191 -------LSG----------------W------------------DNLKEYDLSHIKTLRLSSCG 214

Human   257 ISAKDHTSMRMNVAKVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSNQLID---- 317
            :|.|       ::.|:|:.                          .:|:|:||||.|.|..
Yeast   215 LSYK-------HIGKLLKS--------------------------FRTLKMLDLSYNNLTSAGIQ 246

Human   318 --ENQLYLIAHLP-RLEQLILSDTGISSLHFPDAGIGCKTSMFP---SLKYLVVNDNQIS----- 371
              ||:      :| .||:|.:|  |.:.:.||         :||   :||.|.|::||||
Yeast   247 NFENE------IPCTLEELNIS--GNNLISFP---------LFPKNLTLKGLNVSNNQISRAPSI 294

Human   372 ----------------QWSFFNELEK-LPSLRALSCLRNPLTKE----DKEAETARLLIIASIGQ 415
                            :.|..::|.| .|||:.:....|.....    :.|.:.....::|...:
Yeast   295 AIYSVESLDITDNKFKERSLIDDLNKTFPSLKNIHLSGNEFNYNGNYINVEEQATFYEVLARFDR 359

Human   416 LKTLNK--CEILPEERRRAELDY-RKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYG 477
            :..||.  |::  :.||.||:.: .|...||              ||.:  |..||:..|...|.
Yeast   360 VMVLNGSICDV--KTRREAEMFFVSKVMNNE--------------LSYD--TNLPRWSSLIKSYE 406

Human   478 APE-----DWELKTQQPLMLKNQLLTLKIKYPHQLDQKVLEKQLPGSMTIQKVKGLLSRLLKVPV 537
            ...     :.|.:|:|.|:||.::...| |....||..||.     |.|::.||.::.|.|...:
Yeast   407 IDMSKLSFNNERETRQSLVLKIKIRAGK-KPSSDLDYWVLP-----SFTVRYVKSVICRKLNFDI 465

Human   538 SDLLLSYESPKKPGREIELENDLKSLQFYSVENGDCLLV 576
            .::.|.:|:.:  |...|::.:.:.:..::|.|||.:.|
Yeast   466 LNVKLFHENSE--GMINEIKYNFRPISDFNVVNGDIIHV 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBCE	NP_001274730.1	CAP_GLY	10..75	CDD:460154	26/69 (38%)
		LRR	113..>396	CDD:443914	74/318 (23%)
		leucine-rich repeat	129..154	CDD:275380	7/28 (25%)
		leucine-rich repeat	155..180	CDD:275380	6/24 (25%)
		leucine-rich repeat	181..205	CDD:275380	10/23 (43%)
		leucine-rich repeat	206..281	CDD:275380	11/74 (15%)
		Ribosomal_S21e	234..>272	CDD:460133	8/37 (22%)
		leucine-rich repeat	282..304	CDD:275380	0/21 (0%)
		leucine-rich repeat	305..329	CDD:275380	10/30 (33%)
		leucine-rich repeat	330..359	CDD:275380	9/31 (29%)
		leucine-rich repeat	385..415	CDD:275380	4/33 (12%)
		Ubl_TBCE	495..577	CDD:340564	21/82 (26%)
PAC2	NP_010922.1	CAP_GLY	5..72	CDD:214997	27/70 (39%)
		LRR	45..>333	CDD:443914	92/383 (24%)
		leucine-rich repeat	154..179	CDD:275380	6/24 (25%)
		leucine-rich repeat	180..204	CDD:275380	15/64 (23%)
		leucine-rich repeat	205..229	CDD:275380	6/56 (11%)
		leucine-rich repeat	256..277	CDD:275380	9/31 (29%)
		leucine-rich repeat	278..298	CDD:275380	8/19 (42%)
		leucine-rich repeat	299..324	CDD:275380	3/24 (13%)
		Ubl1_cv_Nsp3_N-like	<445..502	CDD:475130	15/63 (24%)