Protein Alignment TBCE and tbce

DIOPT Version :10

• Sequence 1: NP_001274730.1
• Gene: TBCE / 6905
• HGNCID: 11582
• Length: 578
• Species: Homo sapiens
• Sequence 2: NP_001035078.2
• Gene: tbce / 664760
• ZFINID: ZDB-GENE-051030-120
• Length: 521
• Species: Danio rerio
• Alignment Length: 572
• Identity: 273/572 - (47%)
• Similarity: 360/572 - (62%)
• Gaps: 57/572 - (9%)

Human     8 DVIGRRVEVNGEHATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGSFIRP 72
            :.:||||..:||..|||:.|.|||.||.|||||||:||||||||||:|..||.|||||||||:||
Zfish     5 EAVGRRVCCDGERGTVRYVGPVPPTAGVWLGVEWDHPERGKHDGSHDGVRYFTCRHPTGGSFVRP 69

Human    73 NKVNFGTDFLTAIKNRYVLEDGPEEDRKEQIVTIGNKPVETIGFDSIMKQQSQLSKLQEVSLRNC 137
            .|.:||.|::||:|.||.:|  .||...|: :.|.:|.|..:||:::.|:|| :..|.||.||.|
Zfish    70 QKASFGVDYVTALKQRYEVE--IEEVTAEE-MKISSKTVVMVGFENVKKKQS-VKNLTEVGLRRC 130

Human   138 AVSCAGEKGGVAEACPNIRKVDLSKNLLSSWDEVIHIADQLRHLEVLNVSENKLKFPSG-SVLTG 201
            .||..|.:..:....|.::.:|||.||||||:.:..|.:||..|:.|::|.|:|...|. |.|:.
Zfish   131 EVSAPGPENEIRNTTPFVQSLDLSGNLLSSWEVLAAITEQLDSLQELHLSHNRLSISSAPSSLSS 195

Human   202 TLSVLKVLVLNQTGITWAEAHAQCGGSRHGLDMQKDASKFVDLCVLQKCSTSNCIISAKDHTSMR 266
            ..|.|:||.:|...:||.:
Zfish   196 AFSHLRVLSINSCALTWTQ---------------------------------------------- 214

Human   267 MNVAKVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSNQLIDENQLYLIAHLPRLE 331
                 ||.|......:|||||..|||....||..|||.:.:||||:||:..|..|. |:||||||
Zfish   215 -----VLHCAPMWQQVEELYLADNNITELLRPEHVLQALTVLDLSNNQIAQETVLE-ISHLPRLE 273

Human   332 QLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLT 396
            :|.||.|.:|.:.|.|...|.||::||:||.|:::||.||:|...|||||||||..|||.||||.
Zfish   274 RLNLSSTSLSEIKFSDVPAGKKTTLFPALKELLLDDNNISEWRVVNELEKLPSLVYLSCRRNPLL 338

Human   397 KEDKEAETARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEE 461
            .::|..||||.::||.:|||:.|:..:||.:|||.|||||.|.||:.|.:||||::.|||..:.:
Zfish   339 HKEKNLETARQIMIARLGQLELLDMRQILSDERRGAELDYCKMFGSAWLRAGGHREAEKNNPNTD 403

Human   462 FLTAHPRYQFLCLKYGAPEDWELKTQQPLMLKNQLLTLKIKYPHQLDQKVLEKQLPGSMTIQKVK 526
            |:|.||||..|..|||||::.||:.|:|..|||||||:....|..|::|.:||:|||||.:||||
Zfish   404 FMTEHPRYLTLIQKYGAPDEGELREQKPFALKNQLLTITFLCPEDLERKPIEKKLPGSMIVQKVK 468

Human   527 GLLSRLLKVPVSDLLLSYESPKKPGREIELENDLKSLQFYSVENGDCLLVRW 578
            |||.||||:|..:|.|:|...|...||||::||||.|||||||:||.:||||
Zfish   469 GLLHRLLKLPGVELKLTYTCAKMADREIEIDNDLKPLQFYSVEDGDKILVRW 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBCE	NP_001274730.1	CAP_GLY	10..75	CDD:460154	46/64 (72%)
		LRR	113..>396	CDD:443914	108/283 (38%)
		leucine-rich repeat	129..154	CDD:275380	9/24 (38%)
		leucine-rich repeat	155..180	CDD:275380	12/24 (50%)
		leucine-rich repeat	181..205	CDD:275380	8/24 (33%)
		leucine-rich repeat	206..281	CDD:275380	9/74 (12%)
		Ribosomal_S21e	234..>272	CDD:460133	0/37 (0%)
		leucine-rich repeat	282..304	CDD:275380	12/21 (57%)
		leucine-rich repeat	305..329	CDD:275380	11/23 (48%)
		leucine-rich repeat	330..359	CDD:275380	13/28 (46%)
		leucine-rich repeat	385..415	CDD:275380	15/29 (52%)
		Ubl_TBCE	495..577	CDD:340564	48/81 (59%)
tbce	NP_001035078.2	CAP_GLY	7..71	CDD:460154	46/63 (73%)
		leucine-rich repeat	122..144	CDD:275380	9/21 (43%)
		LRR 1	147..168		9/20 (45%)
		leucine-rich repeat	148..173	CDD:275380	12/24 (50%)
		LRR	151..>364	CDD:443914	105/264 (40%)
		LRR 2	173..194		7/20 (35%)
		leucine-rich repeat	174..199	CDD:275380	8/24 (33%)
		LRR 3	199..220		9/71 (13%)
		leucine-rich repeat	200..224	CDD:275380	9/74 (12%)
		LRR 4	224..245		10/20 (50%)
		leucine-rich repeat	225..247	CDD:275380	12/21 (57%)
		LRR 5	247..268		9/21 (43%)
		leucine-rich repeat	248..271	CDD:275380	11/23 (48%)
		LRR 6	271..292		10/20 (50%)
		leucine-rich repeat	272..301	CDD:275380	13/28 (46%)
		LRR 7	301..322		10/20 (50%)
		leucine-rich repeat	302..326	CDD:275380	14/23 (61%)
		Ubl_TBCE	437..519	CDD:340564	48/81 (59%)