Protein Alignment TAFAZZIN and Tafazzin

DIOPT Version :10

• Sequence 1: NP_001427785.1
• Gene: TAFAZZIN / 6901
• HGNCID: 11577
• Length: 310
• Species: Homo sapiens
• Sequence 2: NP_001167018.1
• Gene: Tafazzin / 66826
• MGIID: 109626
• Length: 263
• Species: Mus musculus
• Alignment Length: 311
• Identity: 254/311 - (81%)
• Similarity: 256/311 - (82%)
• Gaps: 49/311 - (15%)

Human     1 MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSCFWTSEWAQAEAGPPGYPCPAGEYMNHLTVHNR 65
            |||||||||||||.||||||||||||||||||||||                  :|||||||||:
Mouse     1 MPLHVKWPFPAVPRLTWTLASSVVMGLVGTYSCFWT------------------KYMNHLTVHNK 47

Human    66 EVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHF 130
            ||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    48 EVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHF 112

Human   131 FSLGKCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNHGDWVHI 195
            |||||||||||                              ||||||||||||||||||||||||
Mouse   113 FSLGKCVPVCR------------------------------GDGVYQKGMDFILEKLNHGDWVHI 147

Human   196 FPEGKVNMSSEFLRFKW-GIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGK 259
            ||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||
Mouse   148 FPEGKVNMSSEFLRFKWVGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGK 212

Human   260 PFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQPGR 310
            |||.||||||||||||||||||||||||||||||.||.||||||||.||||
Mouse   213 PFSTLPVLERLRAENKSAVEMRKALTDFIQEEFQRLKMQAEQLHNHFQPGR 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TAFAZZIN	NP_001427785.1	None
Tafazzin	NP_001167018.1	LPLAT_AGPAT-like	34..242	CDD:153251	202/255 (79%)
		HXXXXD motif. /evidence=ECO:0000250|UniProtKB:Q3TFD2	69..74		4/4 (100%)
		Mitochondrial targeting sequence. /evidence=ECO:0000250|UniProtKB:Q16635	82..92		9/9 (100%)