DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNTN2 and Cont

DIOPT Version :9

Sequence 1:	XP_024305154.1	Gene:	CNTN2 / 6900	HGNCID:	2172	Length:	1200	Species:	Homo sapiens
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1009	Identity:	318/1009 - (31%)
Similarity:	473/1009 - (46%)	Gaps:	77/1009 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    49 GPVFEDQPLSVLFPEESTE--EQVLLACRARASPPATYRWKMNG------TEMKLEP--GSRHQL 103
            ||.|..||....|......  ..|.|:|.|...|..:|.|....      ...|::|  ..|:.:
  Fly   361 GPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTI 425

Human   104 VGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPC 168
            .||||:|..|.:|.|.|.|.|:|.|..|.:.|..|.|.|||:.||:. :|....:...||..:.|
  Fly   426 SGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNL-KRSAETSEMNWGKSIFC 489

Human   169 NPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSC-LATSHMDFSTKS 232
            :||.|||.:.|.|..:.||||:..|.|.|||: .|.||.:.....|..|||| :.|...|.....
  Fly   490 DPPQHYPDVRYYWARDYFPNFVEEDQRVFVSR-DGALYFSFIETVDRANYSCTVQTLVSDTGRNG 553

Human   233 VFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQW 297
            .|........:.....:||.:....||....|  |.::.|||.|||.|:|...|.:....|....
  Fly   554 PFFPLRVTPNSNYQALIFANTFPKVFPEAPVA--GDEIRLECMAFGYPIPSYNWTRQGLPLQRNA 616

Human   298 TTAE--PTLQIPSVSFEDEGTYECEAENSKGRDTVQGRII--VQAQPEWLKVISDTEADIGSNLR 358
            .|..  ..|.|.:.:..|.|.|.|...|.  |.|:...|.  :|.:|::...:.|...|..|::.
  Fly   617 YTINYGRVLIIQNATTNDNGEYSCTITNP--RKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVT 679

Human   359 WGCAAAGKPRPTVRWLRNGEPL--ASQNRVEVLAGD----LRFSKLSLEDSGMYQCVAENKHGTI 417
            :.|.|...|.....|.:|.|.|  |:.||...:..|    ::|.:.. :|..||||.|:|:..|.
  Fly   680 FICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKD-KDDAMYQCGAQNQLKTS 743

Human   418 YASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTP 482
            ::||:|.|.::.|.|:.:|:...:.|...|...|.|.|.|||:....|.|..:::.:.....:.|
  Fly   744 FSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRILP 808

Human   483 DGTLIIRNISRSDEGKYTCFAENFMGKANS-TGILSVRDATKITLAPSSADINLGDNLTLQCHAS 546
            .|||.|...||.|||.|||.|.|..|...| ..::.:::...|...|........|.:.|.|.|:
  Fly   809 SGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAA 873

Human   547 HDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKET---IGD---LTILNAQLRHGGKYTCMAQTV 605
            .|..:|:.:.|          |..|...:.|...|   |.|   ||:.|..:|..|.|.|:.::.
  Fly   874 FDELLDIAYVW----------KHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSA 928

Human   606 VDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVR 670
            |:..|.:.:|.:.|.||.||||.|..|..|...:.|..|..|...|..|.:..||.....|..|.
  Fly   929 VNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNVS 993

Human   671 TNPANIEGNAET----AQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLS 731
            |:....|.:..|    |:|:.||||..|||.|.|.|.||.|.||.||....|.|..|.:||..:.
  Fly   994 THVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVG 1058

Human   732 GGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRP-YT 795
            ||||..|:|.:.|.|:..:.|:..|..|.:.::.:|:..|.:..:...|.......|..:.. ||
  Fly  1059 GGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYT 1123

Human   796 PFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPV---QQDMNGIL 857
            .:|||:::.|..|.||||..|:::|||:.|:|||.|..|...:|:..||||:|:   ::::.|.|
  Fly  1124 EYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKL 1188

Human   858 LGYEIRYWKAGDKEAAADRVRTAGLDTS--ARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATT 920
            :|:.::|||...:|  .|.|......|.  |.:.||.|:|.|.|.|.|||.||.||.|......|
  Fly  1189 IGHRLKYWKTTHQE--EDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERT 1251

Human   921 MKPPPRRPPGNIS-WTFSSSSLSIKWDPVVPFRNESAVTGYKM-LYQNDLHLTPTLHLTGKNWIE 983
            .:..|::||.::. :..:.|::.:.|..|.|.::|..|.|||: ::::|.::     :|..|.|
  Fly  1252 YRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQNM-----ITANNTI- 1310

Human   984 IPVPEDIGHALVQIRTTGP-----------GGDG 1006
            :|:.:.: .:.:...|.|.           ||||
  Fly  1311 VPIGQKL-ESYINNLTPGKSYNMRVLAYSNGGDG 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNTN2	XP_024305154.1	Ig	49..142	CDD:325142	33/102 (32%)
		Ig2_Contactin-2-like	144..241	CDD:143204	34/97 (35%)
		Ig	252..337	CDD:325142	25/88 (28%)
		Ig4_Contactin-2-like	341..425	CDD:143205	26/89 (29%)
		Ig5_Contactin	446..518	CDD:319278	26/72 (36%)
		Ig6_Contactin-2	537..616	CDD:143262	22/84 (26%)
		FN3	631..718	CDD:238020	33/90 (37%)
		FN3	739..813	CDD:238020	19/74 (26%)
		FN3	828..920	CDD:238020	36/96 (38%)
		Atrophin-1	<1002..1197	CDD:331285	4/16 (25%)
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	31/98 (32%)
		I-set	362..462	CDD:254352	31/99 (31%)
		Ig	466..559	CDD:299845	34/94 (36%)
		IG_like	584..657	CDD:214653	23/76 (30%)
		IGc2	586..645	CDD:197706	18/58 (31%)
		Ig	667..751	CDD:299845	26/84 (31%)
		IG_like	676..751	CDD:214653	24/75 (32%)
		IG_like	765..844	CDD:214653	27/78 (35%)
		Ig	773..844	CDD:299845	26/70 (37%)
		I-set	851..940	CDD:254352	25/98 (26%)
		Ig	866..944	CDD:299845	23/87 (26%)
		FN3	944..1043	CDD:238020	40/98 (41%)
		FN3	1053..1146	CDD:238020	29/92 (32%)
		fn3	1156..1244	CDD:278470	35/89 (39%)
		fn3	1259..1346	CDD:278470	22/92 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9318
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1415
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm41700
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840