DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBX1 and tbx1

DIOPT Version :9

Sequence 1:	XP_016884414.1	Gene:	TBX1 / 6899	HGNCID:	11592	Length:	545	Species:	Homo sapiens
Sequence 2:	NP_001030290.1	Gene:	tbx1 / 619587	XenbaseID:	XB-GENE-478084	Length:	463	Species:	Xenopus tropicalis

Alignment Length:	502	Identity:	354/502 - (70%)
Similarity:	394/502 - (78%)	Gaps:	61/502 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    52 HFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPPPPRYDPCAAAAPGAPGPPPP 116
            ||.    |:.||||:|||||.|:||:..:.||| |||...|     |.|:||:|:
Frog    15 HFC----DVAAFTANSLSSLNASGGYHLSPSPG-DPYSQHE-----PHYEPCSAS---------- 59

Human   117 PHAYPFA-----PAAGAATS--AAAEPEGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFN 174
            .|:|.|.     |.:||::|  |::.|.......:.::|||||||.|||.::|||||||||||||
Frog    60 QHSYSFGHACPEPESGASSSSCASSTPGSGSTGSSGSSKAPVKKNPKVANITVQLEMKALWDEFN 124

Human   175 QLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPAT 239
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Frog   125 QLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPAT 189

Human   240 PGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEK 304
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   190 PGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEK 254

Human   305 YAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLMSAFA 369
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||:|||
Frog   255 YAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGSLPLMNAFA 319

Human   370 RSRNPVASPTQPSGTEKDAAEARREFQRDAGGPAVLGDPAHPPQLLARVLSPSLPGAGGAGGLVP 434
            ||||||:||.| :|::|| .:.|||::||..|..:.||.|| .||::||||||||   ..|||||
Frog   320 RSRNPVSSPPQ-NGSDKD-GDGRREYERDTSGTPLHGDAAH-QQLMSRVLSPSLP---VPGGLVP 378

Human   435 LPGAPGGRPSPPNPELRLEAPG-ASEPLHHHPYKYPAAAYDHYLGAKSRPAPYPLPGLRGHGYHP 498
            |   ..||||||: ||||:... .|||||||||||| .:||||||||:||||||||.:|||||
Frog   379 L---STGRPSPPH-ELRLDPHSQGSEPLHHHPYKYP-TSYDHYLGAKTRPAPYPLPSIRGHGY-- 436

Human   499 HAHPHHHHHPVSPAAAAAAAAAAAAAAANMYSSAGAAPPGSYDYCPR 545
                  ||||::|            |||||||.|||  ||||:|.||
Frog   437 ------HHHPMNP------------AAANMYSGAGA--PGSYEYGPR 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX1	XP_016884414.1	None
tbx1	NP_001030290.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		11/24 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..103		9/27 (33%)
		T-box	112..297	CDD:366363	183/184 (99%)
		T-box	114..297		181/182 (99%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..354		18/35 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..405		26/44 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	387	1.000	Domainoid score	I6334
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7966
Inparanoid	1	1.050	522	1.000	Inparanoid score	I7409
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185429at2759
OrthoFinder	1	1.000	-	-		FOG0003320
OrthoInspector	1	1.000	-	-		oto151712
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X3735
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.190