Protein Alignment TBX1 and tbx1

DIOPT Version :9

• Sequence 1: XP_016884414.1
• Gene: TBX1 / 6899
• HGNCID: 11592
• Length: 545
• Species: Homo sapiens
• Sequence 2: XP_005168668.1
• Gene: tbx1 / 368206
• ZFINID: ZDB-GENE-030805-5
• Length: 519
• Species: Danio rerio
• Alignment Length: 573
• Identity: 353/573 - (61%)
• Similarity: 408/573 - (71%)
• Gaps: 82/573 - (14%)

Human     1 MDARSPLSPRASAFSIASLVAA--EAAERTAHQGSGSSDRVKL----RWLPGSPAGMHFSTVTRD 59
            ||..|||||:|:|||||.|::|  :|...|..:.:.|.|:..:    |::.     ||:|||||:
Zfish     1 MDDSSPLSPKANAFSIACLISARDQAGNTTFDKHATSLDKQAVQNCSRYIK-----MHYSTVTRE 60

Human    60 ME-----------------AFTASSLSSLGAAGGFPGAASPGADPYGPREPPPPPPRYDPCAAAA 107
            ||                 |||.||||||...|.:..:.||| |||...|     .:::||.||
Zfish    61 MEAISSPWLTQLSHFCDVAAFTTSSLSSLNTPGSYHLSPSPG-DPYSHHE-----SQFEPCPAA- 118

Human   108 PGAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAP----VKKNAKVAGVSVQLEMKA 168
                     .|||.::.:..|...|..:......|.::::..|    ||||.|||.::|||||||
Zfish   119 ---------QHAYNYSGSNSAQAPAQGDSGTSNCSSSSSSSTPNKTLVKKNPKVANINVQLEMKA 174

Human   169 LWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAG 233
            ||||||||||||||||||||||||||||:|||||||||||||||:||||||||||||||||||||
Zfish   175 LWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFLPVDDKRYRYAFHSSSWLVAG 239

Human   234 KADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDP 298
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   240 KADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDP 304

Human   299 RKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGALP 363
            |||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||:|.
Zfish   305 RKDSEKYAEENYKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGSLQ 369

Human   364 LMSAFARSRNPVASPTQPSGTEKDAAEARREFQRDAGGPAVLGDPAHPPQLLARVLSPSLPGAGG 428
            :||||||:|||::||.|.:||||:  ::|||:.||..|..:..||.|  ||::|||||:||..||
Zfish   370 IMSAFARTRNPMSSPPQQNGTEKE--DSRREYDRDPSGNPLHSDPTH--QLMSRVLSPALPVLGG 430

Human   429 AGGLVPLPGAPGGRPSPPNPELRLEA-PGASEPLHHHPYKYPAAAYDHYLGAKSRPAPYPLPGLR 492
            ... |||...|   .|||: ||||:. |...:.||||||||| |.|:||||||:||:|||.|.:|
Zfish   431 LHA-VPLTAGP---RSPPH-ELRLDGHPQPPDTLHHHPYKYP-ATYEHYLGAKTRPSPYPSPSIR 489

Human   493 GHGYHPHAHPHHHHHPVSPAAAAAAAAAAAAAAANMYSSAGAAPPGSYDYCPR 545
            |||||||.:|                     ..|||||:..|  |.:|||.||
Zfish   490 GHGYHPHMNP---------------------TTANMYSATSA--PTNYDYGPR 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX1	XP_016884414.1	None
tbx1	XP_005168668.1	TBOX	165..355	CDD:238106	183/189 (97%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341794
Domainoid	1	1.000	385	1.000	Domainoid score	I4990
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7966
Inparanoid	1	1.050	500	1.000	Inparanoid score	I6493
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185429at2759
OrthoFinder	1	1.000	-	-		FOG0003320
OrthoInspector	1	1.000	-	-		oto45494
orthoMCL	1	0.900	-	-		OOG6_107409
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X3735
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.290