DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TARBP2 and stau

DIOPT Version :9

Sequence 1:NP_599150.1 Gene:TARBP2 / 6895 HGNCID:11569 Length:366 Species:Homo sapiens
Sequence 2:NP_476751.1 Gene:stau / 37065 FlyBaseID:FBgn0003520 Length:1026 Species:Drosophila melanogaster


Alignment Length:468 Identity:106/468 - (22%)
Similarity:157/468 - (33%) Gaps:143/468 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    18 SIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKA 82
            ::|..:.....|:|||.:.|.|.:...|..:.:|:.||.||..||.....||.....|:|..||.
  Fly   566 ALEDSMDEGDKKSPISQVHEIGIKRNMTVHFKVLREEGPAHMKNFITACIVGSIVTEGEGNGKKV 630

Human    83 AKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDIPVFT--AAAAATPVPSVVLTRSPPM 145
            :|.:|||..|..|:....|.|..:     :||     :.|.|.|  .:.||....|||.....|.
  Fly   631 SKKRAAEKMLVELQKLPPLTPTKQ-----TPL-----KRIKVKTPGKSGAAAREGSVVSGTDGPT 685

Human   146 E---------LQPP---VSPQQSECNPVGALQELVVQKGWRLPEYTVTQESG--PAHRKEFTMTC 196
            :         |.||   :.......||:..|.:|...:..:.|.:.:..::|  .|.|:||.|..
  Fly   686 QTGKPERRKRLNPPKDKLIDMDDADNPITKLIQLQQTRKEKEPIFELIAKNGNETARRREFVMEV 750

Human   197 RVERFIEIGSGTSKKLAKRNAAAK----------------------------------------- 220
            ........|:|.||||||||||..                                         
  Fly   751 SASGSTARGTGNSKKLAKRNAAQALFELLEAVQVTPTNETQSSEECSTSATMSAVTAPAVEATAE 815

Human   221 ----------------MLLRVHTVPLDARD----------------GNEV-------------EP 240
                            ::||.:..|...||                ..||             ..
  Fly   816 GKVPMVATPVGPMPGILILRQNKKPAKKRDQIVIVKSNVESKEEEANKEVAVAAEENSNNSANSG 880

Human   241 DDDHFSIG----------------VGSRLDGLRNRGP--GCTWDSLRNSVGEKILSLRSCSLGSL 287
            |..:.|.|                .||...|:.:...  |...|...::..:......|.|..:.
  Fly   881 DSSNSSSGDSQATEAASESALNTSTGSNTSGVSSNSSNVGANTDGNNHAESKNNTESSSNSTSNT 945

Human   288 GALGPACCRVLSELSEEQAFHVSYLDI------EELSLSGLCQCLVELSTQPATVCHGSATTREA 346
            .:.|......|..||:...|.|::.|.      |.|:       :|.|||.|..:|||...:.|.
  Fly   946 QSAGVHMKEQLLYLSKLLDFEVNFSDYPKGNHNEFLT-------IVTLSTHPPQICHGVGKSSEE 1003

Human   347 ARGEAARRALQYL 359
            ::.:||..||:.|
  Fly  1004 SQNDAASNALKIL 1016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARBP2NP_599150.1 Sufficient for interaction with PRKRA 22..105 28/82 (34%)
DSRM_TARBP2_rpt1 27..98 CDD:380719 26/70 (37%)
Sufficient for interaction with PRKRA 152..234 26/140 (19%)
DSRM_TARBP2_rpt2 159..225 CDD:380681 24/124 (19%)
Sufficient for interaction with DICER1 228..366 38/185 (21%)
Sufficient for interaction with PRKRA 287..366 23/79 (29%)
DSRM_TARBP2_rpt3 292..363 CDD:380722 22/74 (30%)
stauNP_476751.1 DSRM 312..375 CDD:214634
DSRM <529..555 CDD:294045
DSRM 579..644 CDD:214634 24/64 (38%)
DSRM 712..780 CDD:214634 22/67 (33%)
Staufen_C <953..1020 CDD:293091 22/71 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3732
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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