Protein Alignment Mast3 and dop

DIOPT Version :9

• Sequence 1: XP_038950759.1
• Gene: Mast3 / 688540
• RGDID: 1587639
• Length: 1337
• Species: Rattus norvegicus
• Sequence 2: NP_001261884.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Alignment Length: 1748
• Identity: 654/1748 - (37%)
• Similarity: 849/1748 - (48%)
• Gaps: 505/1748 - (28%)

  Rat     5 SLLRR----------RGLQKELSLPRRGRGLSPSSQSPCLLS---------------PGSPCSPC 44
            :|||:          |.:..|.|...|.|..|....:|||..               ||...||
  Fly   202 ALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLTGNYFRHELTAPLPVQPPGFGASP- 265

  Rat    45 SPSLG---LQQPWSC---------------------------------RSG---NRKSLVVGTPS 70
               ||   :.:..||                                 .||   :|.|||..:.:
  Fly   266 ---LGGHNISRSGSCAGIGLAKHHHHHHLHGVVMRGSAGGGAGSGGGSSSGVAHHRLSLVTNSAA 327

  Rat    71 PTL---SRPLSPLSVPTAGNSPLDSPRNFSAAAAINFPFARRQLSHSDRADGRRWSLASLPSSGY 132
            ...   ||..||.|.     ||:||||..|.......|..|........|||||||:||||||||
  Fly   328 VAAAGGSRTHSPYSA-----SPVDSPRLNSPMPFAFAPIKRIASCRGVVADGRRWSVASLPSSGY 387

  Rat   133 GTNTPSSTVSSSSSSRERLHQL-----PFQPTADE---------LRFLSKH-------------- 169
            ||...||.:||..||:|.|:||     |....||.         ...|.:|
  Fly   388 GTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLAVSQK 452

  Rat   170 ------------------------------------------------FRSSESVVDEDGGR-SP 185
                                                            ..||.|...:.||| ||
  Fly   453 QLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSP 517

  Rat   186 RLRPRSRSLSPGRTSGTFDNEIVMMNHVYRERFPKATAQMEGRLQDFLAAFAPGDRLALADG--V 248
            ..||||||||....|...||||.:||.:|:|||||||.|||.||:.|:.........:..|.  :
  Fly   518 YFRPRSRSLSSPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFRDSQPI 582

  Rat   249 LGFIHHQIVELARDCLAKSGEALVTSRYFLEMQDKLERLLQDAHERSD--SAEVGFIVQLVRKLL 311
            :.|:|||::|:|||||.||...|:||:||.|:.:.|||||.:..|:|.  :||:..:   ::|||
  Fly   583 VRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKSPEAAAELNGV---IKKLL 644

  Rat   312 IIISRPARLLECLEFDPEEFYHLLEAAEGQAREDQGVKTDLPRYIIRQLGLAKDPLEEIQ----- 371
            :||||||||||||||||:|||.|||||||.|:....:|.|:|:|||.:|||.:||:.|:|
  Fly   645 LIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAELQQELRE 709

  Rat   372 --------------------------PLND--------------LDEG-------QPP------- 382
                                      ||..              :|.|       |||
  Fly   710 TQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATC 774

  Rat   383 --AP--------------GSPESRGLG----------------------GPSRRQPCESDFETIK 409
              ||              ||..:.|.|                      |..:..|.|:||:.:|
  Fly   775 DTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPSPQENDFDIVK 839

  Rat   410 LISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVGMFCSFET 474
            |||||||||||||:|:.||||||:|||||.|||||||::|||.|||||:||:|||||.|:|||||
  Fly   840 LISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFET 904

  Rat   475 RRHLCMVMEYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSL 539
            ::|||:||||||||||.|||||:||||.||||.||||||||:||||:||||||||||||||||:|
  Fly   905 KKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITAL 969

  Rat   540 GHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFVDKQVCGTPEYIAPEVIFRQGYGKPVDWWAM 604
            ||||||||||||:||||:|||||||:|:.:.|:|.||||.|||||||||||.|||||||||||:|
  Fly   970 GHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSM 1034

  Rat   605 GVILYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDE-ALPPDAQDLITRLLRQSPMDRLGT-G 667
            |:||||||:|||||||:|.||||...|:|:|.||:.:: .:..:|:|:|::||:|:|.||||| .
  Fly  1035 GIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQS 1099

  Rat   668 GTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFDTRSERYRH-LGSEGDETNDEESSTE 731
            |..|:|:|.:||.:||..|||.||||||||..:|||||||||.:||.| ||  |::|:|.:.:..
  Fly  1100 GALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDLG--GEDTDDTDDTPV 1162

  Rat   732 IPQFSSCSHRFSKV-YSSSEFLA---------VQPNPTFAERSFSEDR----------------E 770
            ...|:|.:.::.|. ||.|....         ..|.|..:..|.:::.                :
  Fly  1163 FGSFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGATSTGALPKLK 1227

  Rat   771 EGW---EQSGEGDGGRRLSTD---------LRLRSWTPASSCQPSSCQSDRGPSPSLLSTIS--- 820
            .|.   ..||.|.|....|.|         .:||....:|||.......|....|.||..::
  Fly  1228 SGMGSGSGSGSGSGSGSASHDGVVNKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGN 1292

  Rat   821 ---LDMPKFAFSSEDEGA-------GSGPADTRKPVFILGEPDPPPPT--------TPVTPKPCN 867
               |.|.|......:.||       .|.|.:|   ..|:..|..||||        ||.|....:
  Fly  1293 DAELRMLKHYLQQPNPGATQRMQQRHSMPPNT---TTIISTPATPPPTQTQATMAATPPTATVGS 1354

  Rat   868 LSADTAVLSHA-------RLRSNSTG--ARHSTPR--------PLDAGRG--RRLGSSRDPGP-- 911
            .|..|...|..       ::.....|  ||...||        .:.||..  ..:...|:..|
  Fly  1355 FSRSTPESSQTDSDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLA 1419

  Rat   912 --EKPRASPGGSGG---------RVPKSASVSALSLIITADDGSGGP----LMSPLSPRSLSSNP 961
              .:|::..|.:.|         .:.||||...|||:.:.|:.....    :.||....:.||..
  Fly  1420 LQHQPKSMDGSTSGSSVKHHRSRSIVKSASALGLSLMTSLDNSQLAAQLCGIQSPGGGGNGSSTA 1484

  Rat   962 SSRDSSPSRDPSPVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEEGSPAQE 1026
            ||||:||.|:.||:..:|:|||:|....:.:||::..||||.||:|.||:||:|.:|:|||||.|
  Fly  1485 SSRDTSPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFE 1549

  Rat  1027 AGLRAGDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMA-- 1089
            ||||..|||||:|||:|.||.|..|::|||..|..::||.|.||:|||:.|..::::.:.::|
  Fly  1550 AGLRPADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKK 1614

  Rat  1090 ---RRSKRSRRRETQDRRKSLFKRISK-------------------PS--------SVLHTS--R 1122
               |:.|:::|...:.|:.|||:|||.                   ||        |..|:|  :
  Fly  1615 GVNRQKKQTKREHDKKRKTSLFRRISSKRANAEMQQYSAGTSSPTTPSARNLSPLDSSYHSSCCQ 1679

  Rat  1123 SFSSGLQHSLSSSESLPGSPTHS-------------LSPSPTTPCRSPAPDVPTDTASPPSV--- 1171
            |.::....|.|.|.|.|.:||.|             ::||..: .:.|:...||.....|.|
  Fly  1680 SAANSSSQSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALS-VQLPSAPPPTQLVLLPHVGAV 1743

  Rat  1172 ---SPSS--SSPASPATG-----HTRPSSLHGLAAKL----------GPPRHKSG---------- 1206
               :|:|  :.|.|| ||     :.|||:||||..||          |...:.:|
  Fly  1744 VGSNPTSVGNVPVSP-TGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNN 1807

  Rat  1207 -----RRKSTSSIPPSPLACPPVPTP----PPRSPSPLP----GHIP--------------IP-- 1242
                 ||||...||.||||..|.|:|    |.||||||.    ||.|              :|
  Fly  1808 NSLPNRRKSVGHIPLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSYSPGSTLPTL 1872

  Rat  1243 -------------AR-------SPRLRRGQSADKLGLGTSERLDGDGGRRGRGAETEL 1280
                         ||       ||.|||..|.|:|              ..|.|||::
  Fly  1873 QTAVNANTKKAGFARTKSAEPSSPLLRRALSPDRL--------------HPRSAETKI 1916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mast3	XP_038950759.1	DUF1908	89..369	CDD:401031	146/360 (41%)
		STKc_MAST	404..683	CDD:270760	206/280 (74%)
		PDZ_signaling	987..1064	CDD:238492	42/76 (55%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	146/360 (41%)
		STKc_MAST	834..1115	CDD:270760	206/280 (74%)
		S_TKc	835..1110	CDD:214567	203/274 (74%)
		PDZ_signaling	1506..1587	CDD:238492	44/80 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347619
Domainoid	1	1.000	441	1.000	Domainoid score	I522
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	977	1.000	Inparanoid score	I297
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm45536
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.890