DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K7 and FPK1

DIOPT Version :9

Sequence 1:	NP_663304.1	Gene:	MAP3K7 / 6885	HGNCID:	6859	Length:	606	Species:	Homo sapiens
Sequence 2:	NP_014445.1	Gene:	FPK1 / 855783	SGDID:	S000005330	Length:	893	Species:	Saccharomyces cerevisiae

Alignment Length:	481	Identity:	99/481 - (20%)
Similarity:	175/481 - (36%)	Gaps:	172/481 - (35%)

- Green bases have known domain annotations that are detailed below.

Human     3 TASAASSSSSSS------AGEMIEAPS---------QVLNFEE--------------------ID 32
            |:|:|..:|.||      .|:.:..|:         ::.:|.|                    :.
Yeast   428 TSSSARKTSGSSNINDKIPGQSVPPPNSFFPQEPSPKISDFPEPRRSRRLRTKSFSNKFQDIMVG 492

Human    33 YKEIEVEEVVGRGAFGVVCKAKWR-----------AKDVAIKQIESESERKAFIVELRQLSRVNH 86
            .:..|...::|:|..|.|...:.:           :||..||:    ::.|..:.|...|:..||
Yeast   493 PQSFEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKR----NKIKRVLTEQEILATSNH 553

Human    87 PNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP 149
            |.||.||.:..:.  :.|.|||..||..:..|. ...........|..:..:.:..:.|||.:
Yeast   554 PFIVTLYHSFQSEDYLYLCMEYCMGGEFFRALQ-TRKTKCICEDDARFYASEVTAALEYLHLL-- 615

Human   150 KALIHRDLKPPNLLLVAGGTVLKICDF---------------GTACDIQTHMTNNK--------- 190
             ..|:|||||.|:||...|.:: :.||               |:|   |:.:.:.|
Yeast   616 -GFIYRDLKPENILLHQSGHIM-LSDFDLSIQAKDSKVPVVKGSA---QSTLVDTKICSDGFRTN 675

Human   191 ---GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPF----------------------D 230
               |:..::||||..|:.::...|.::.||:::|::....||                      :
Yeast   676 SFVGTEEYIAPEVIRGNGHTAAVDWWTLGILIYEMLFGFTPFKGDNTNETFTNILKNEVSFPNNN 740

Human   231 EIG------------------------------GPAF-RIMWAVHNGTRPPLIKNLPK------P 258
            ||.                              .|.| ::.|::.....||||..|.:      .
Yeast   741 EISRTCKDLIKKLLTKNESKRLGCKMGAADVKKHPFFKKVQWSLLRNQEPPLIPVLSEDGYDFAK 805

Human   259 IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEG------------QSN 311
            :.|...|..|:|..:.  ::|..|.|         .:|.::|..:.|::.            |.|
Yeast   806 LSSNKKRQTSQDSHKH--LDEQEKNM---------FEERVEYDDEVSEDDPFHDFNSMSLMEQDN 859

Human   312 SAT---STGSFMDIASTNTSNKSDTN 334
            ::.   :|.|:..||.|..||:|.:|
Yeast   860 NSMIYGNTNSYGKIAYTPNSNRSRSN 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K7	NP_663304.1	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		86/430 (20%)
		STKc_TAK1	42..292	CDD:270960	74/348 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..493
FPK1	NP_014445.1	STKc_phototropin_like	494..797	CDD:270726	67/314 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910