DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K7 and ARK1

DIOPT Version :9

Sequence 1:	NP_663304.1	Gene:	MAP3K7 / 6885	HGNCID:	6859	Length:	606	Species:	Homo sapiens
Sequence 2:	NP_014378.1	Gene:	ARK1 / 855711	SGDID:	S000004965	Length:	638	Species:	Saccharomyces cerevisiae

Alignment Length:	531	Identity:	129/531 - (24%)
Similarity:	220/531 - (41%)	Gaps:	106/531 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   100 VCLVMEYAEGGS--------LYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRD 156
            |.::|||.|.|.        |.|.||..|.|      ..||   |.:||||.:|::|| .|||||
Yeast   105 VFVLMEYCERGGLIDFMNTRLQNRLHEFEIL------QIMS---QVTQGVAAMHALQP-PLIHRD 159

Human   157 LKPPNLLLVAGGTVLKICDFGTACDI-------------QTHMTNNKGSAAWMAPEV---FEGSN 205
            :|..|:|:.|... .|:||||:.|.|             |..:..|. :|.:.:||:   |.|..
Yeast   160 IKIENVLISANNE-YKLCDFGSVCGIIRPPRNSQELSYVQQDILKNT-TAQYRSPEMIDTFRGLP 222

Human   206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMTRCWSK 269
            ..||.|:::.||.|:::.....||:: ||..     |:.:|. ..||..|..:.::.|:.....:
Yeast   223 IDEKSDIWALGIFLYKLCYYTTPFEK-GGDL-----AILSGKFEFPLYPNYSEQLKGLIRDILVQ 281

Human   270 DPSQRPSMEEIVKIMTHLMRYFP---GADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKS 331
            ||..||::.:::|.:: :|:..|   ...:.:|.|..:.:..:.:..::|.:.:.:.|..|...:
Yeast   282 DPRHRPNVYQLLKRIS-IMQNVPCPINDIQVVQAPSSHLNLTELHQLSATQNILSLNSPTTMENT 345

Human   332 DTNME-QVPATNDTI------KRLESKLLKNQAKQQSESGRLSLGASRGSSVESL-PPTSEGKRM 388
            ..|.. |:...::|.      .|..|::..:.:...|..|...|.....:...:| ||..|....
Yeast   346 MPNATFQISMADNTTTAQMHPNRKPSQIAYDASFSNSAKGSQPLFDKSQNMYHALDPPLVEPLAS 410

Human   389 SADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVP--------EIVISGNGQPRRRSIQDLTV 445
            |...::.|.:..:.|...:.......|....|.:|.|        |...|.:.:.....:.:|..
Yeast   411 SVSNNDNELKANSATKLKQAIVSEAHTFRQNNSIDFPLQNIIPQYEDSSSSSDESYSGDVDELKK 475

Human   446 TGTEPGQVSSRSS---SPSVRMITTSG--------PTSEKPTRSHPWTPDDSTDTNGSDNSIPMA 499
            | ...|..|:|.:   :.||:...||.        |||.|....|..:|..||..|..|||
Yeast   476 T-RSLGSYSTRGNIKKNQSVKESLTSSSLPGTSFTPTSTKVNLKHENSPFKSTFVNTIDNS---- 535

Human   500 YLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNT 564
               .|...:|      |.|.:.|.:|:.|.:.:               |.::.:|:..| :..|.
Yeast   536 ---KDDLNKP------SYEDLDVSKQNLKNSIQ---------------QRMIDKLNSSE-ESFNA 575

Human   565 SRL--VQEHKK 573
            .::  |:.|:|
Yeast   576 RKMSKVKLHEK 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K7	NP_663304.1	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		68/227 (30%)
		STKc_TAK1	42..292	CDD:270960	67/216 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..391		8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..493		18/60 (30%)
ARK1	NP_014378.1	STKc_NAK_like	18..301	CDD:270939	67/214 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910