Protein Alignment MAP3K7 and slpr

DIOPT Version :9

• Sequence 1: NP_663304.1
• Gene: MAP3K7 / 6885
• HGNCID: 6859
• Length: 606
• Species: Homo sapiens
• Sequence 2: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 149/530 - (28%)
• Similarity: 226/530 - (42%)
• Gaps: 127/530 - (23%)

Human    12 SSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESE------ 70
            ||:.|:        :...||:|.|::::||:|.|.|..|.:..:..::||||......|
  Fly   113 SSAIGD--------IQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRM 169

Human    71 RKAFIVELRQLSRVNHPNIVKLYGACLN-PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWC 134
            |...:.|.:....:.|.||..|.|.||| .:|||||||.||||..:|.|..|...     .::|.
  Fly   170 RDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAGKIPPDV-----LVNWA 229

Human   135 LQCSQGVAYLHSMQPKALIHRDLKPPNLLL---VAGG----TVLKICDFGTACDI-QTHMTNNKG 191
            :|.::|:.|||:..|.::||||||..|:|:   :.|.    ..|||.|||.|.:: .|...:..|
  Fly   230 IQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAG 294

Human   192 SAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH-NGTRPPLIKNL 255
            :.|||.|||...|.||:..||:|:|::|||:||...|:.  |.....:.:.|. |....|:.|..
  Fly   295 TYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYK--GFDPLSVAYGVAVNTLTLPIPKTC 357

Human   256 PKPIESLMTRCWSKDPSQRPSMEEIVKIMT---------------HLM----------------- 288
            |:...:||..||..||.:||..:||:|.:.               |.|
  Fly   358 PETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLRE 422

Human   289 --RYFPGADEPLQYPCQYSDEGQ----SNSATSTGSFMDIASTNTSNKSDTNMEQ-------VPA 340
              :.|...:|.|:     :.|.|    .|......:.:.|...|...:....:|:       ||:
  Fly   423 KEKRFQTIEEELR-----NKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPS 482

Human   341 TNDTIKRLESKLLKNQAKQQS-ESG-RLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATT 403
                 ||...|..||:..|.| .:| |.::.|.|..:.:...|:..|.|:          :|.|.
  Fly   483 -----KRKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRI----------VALTD 532

Human   404 AYS----KPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRM 464
            .:.    .|...|::..|.     :|. .:|| |||.            .|.|.|:.||
  Fly   533 GHKGKTWGPSTMHQRERSL-----LPS-QLSG-GQPE------------WPAQTSTHSS------ 572

Human   465 ITTSGPTSEK 474
            .:.|.|..:|
  Fly   573 FSKSAPNLDK 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K7	NP_663304.1	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		108/337 (32%)
		STKc_TAK1	42..292	CDD:270960	96/299 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..338		6/47 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..391		11/38 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..493		8/32 (25%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	96/263 (37%)
		STKc_MLK	134..389	CDD:270963	95/261 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346131at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820