Protein Alignment MAP3K7 and map3k7

DIOPT Version :9

• Sequence 1: NP_663304.1
• Gene: MAP3K7 / 6885
• HGNCID: 6859
• Length: 606
• Species: Homo sapiens
• Sequence 2: XP_012818037.1
• Gene: map3k7 / 100101764
• XenbaseID: XB-GENE-481530
• Length: 617
• Species: Xenopus tropicalis
• Alignment Length: 617
• Identity: 542/617 - (87%)
• Similarity: 567/617 - (91%)
• Gaps: 23/617 - (3%)

Human    12 SSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV 76
            |:::.:|||.| .|||||||||||||||||||||.||||||||||.|||||||||||||||||||
 Frog     2 SAASADMIETP-PVLNFEEIDYKEIEVEEVVGRGTFGVVCKAKWRGKDVAIKQIESESERKAFIV 65

Human    77 ELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 141
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
 Frog    66 ELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCAQGV 130

Human   142 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNY 206
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   131 AYLHSMKPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNY 195

Human   207 SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDP 271
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDP 260

Human   272 SQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNME 336
            .||||||||||||||||:||||||..|||||||||||||||||||||.:||.|||||||||.|:|
 Frog   261 PQRPSMEEIVKIMTHLMQYFPGADVSLQYPCQYSDEGQSNSATSTGSCIDITSTNTSNKSDINIE 325

Human   337 ----QVPATNDTIKRLESKL---LKNQAKQQSESGRLSLGASRGSSVESL------PP----TSE 384
                |..|:||||||:||||   ||||:||..|:|||||..|||||||||      ||    |||
 Frog   326 AGDFQASASNDTIKRIESKLAQHLKNQSKQSGETGRLSLPPSRGSSVESLSEIRGRPPSTLGTSE 390

Human   385 GKRMSADMSEIEARIAATT-AYSKPKRGHRKTASFGNILDVPEIVI-SGNGQPRRRSIQDLTVTG 447
            ||||||||||:||||:|:| ||:|||||||||||||||||||||:| :||||.||||:||||:.|
 Frog   391 GKRMSADMSELEARISASTAAYAKPKRGHRKTASFGNILDVPEIIITAGNGQQRRRSVQDLTIVG 455

Human   448 TEPGQV---SSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQP 509
            ||..|.   ||||||||||||||||||.:||.|..||.||:|:||||||||||||||||||||||
 Frog   456 TESSQESRNSSRSSSPSVRMITTSGPTPDKPPRGLPWGPDESSDTNGSDNSIPMAYLTLDHQLQP 520

Human   510 LAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKL 574
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
 Frog   521 LAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELIAELDQDEKDQQNTSRLVQEHKKL 585

Human   575 LDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS 606
            ||||||||||||||||||||||||||||||||
 Frog   586 LDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K7	NP_663304.1	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		271/287 (94%)
		STKc_TAK1	42..292	CDD:270960	243/249 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..338		31/40 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..391		30/46 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..493		36/52 (69%)
map3k7	XP_012818037.1	STKc_TAK1	31..281	CDD:270960	243/249 (98%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	530	1.000	Domainoid score	I3250
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H135715
Inparanoid	1	1.050	1065	1.000	Inparanoid score	I2788
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG44254
OrthoDB	1	1.010	-	-		D121068at7742
OrthoFinder	1	1.000	-	-		FOG0000676
OrthoInspector	1	1.000	-	-		oto158070
Panther	1	1.100	-	-	LDO	PTHR46716
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5367
SonicParanoid	1	1.000	-	-		X4191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110