DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mypn and zormin

DIOPT Version :9

Sequence 1:	NP_892037.2	Gene:	Mypn / 68802	MGIID:	1916052	Length:	1315	Species:	Mus musculus
Sequence 2:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster

Alignment Length:	1430	Identity:	269/1430 - (18%)
Similarity:	461/1430 - (32%)	Gaps:	507/1430 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 DSIEASTSISQLLRESYLAETRHRGDNERSRAEPSSNPFHFSGPGAAEGGGPEDLPDLSA----- 63
            ||:||...::.:  |:|:..   |....||:.:.:|...|             |:..:|:
  Fly  1130 DSVEAGNLVNDI--ENYVTS---REAALRSKLDSASQCAH-------------DMNKVSSLYNDV 1176

Mouse    64 ---FLSQEELDESVNLARLAIN-------------HDPLER---VDEAQARKRLSSDQ----TKH 105
               |.|..:|...:|:.:..:.             .|..||   :.||:|::||..::    ...
  Fly  1177 MNIFQSFIKLKMDINVVQERLKQEQRQKEQRERDARDQAEREKAIKEAEAKERLHREEQSRLENQ 1241

Mouse   106 ASKPSFEPAFHQDSSRGPASPKDSPPETK------RPQYSSETQSKKVFLNKAADFIEELSSLFK 164
            ..:.:.|.|..:.::|..|..:.:..|.:      |.|.:.|..:::....:....|:.|..:.:
  Fly  1242 RQQAAIEQAQRELAARELALREQAVREEEARLQAIREQATREQLAREQAAREEELRIQSLRDIAR 1306

Mouse   165 AHSSKRIRPRACKNHKSKTESQNKVLQENSPTFSDLTERRERASVPIPIPADSRDNELNHAIEQR 229
            .....|::....:..:.:.|.:.::.:||    ...::|.|.|.:                  ||
  Fly  1307 REEEVRLQNIRDEETRIRREEEERIRREN----ESRSKREEEARI------------------QR 1349

Mouse   230 EAKRR--------EAELAAGEAAAGDSTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGSRVQL 286
            |...|        :.:....|....|....|..:.|.|..||     ||:.|:.....||.|...
  Fly  1350 EEITRLQTLRDQVDQQRIVTENIRKDIQVNSIFTELRYASPL-----FTRPLKDAVSREGDRFVF 1409

Mouse   287 DCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS 351
            :|.|.|.|.|.|.|:.:|..::.:.|........:..|.|.|.|..|:.|:||.|||:.||..|:
  Fly  1410 ECEVTGTPEPAVEWFKDGISIQTNSDYKTTFDKGICRLVIEETFAADSARFSCRASNLVGTCDTN 1474

Mouse   352 AEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAAIPPAAEAQPLAAQPRVSTVQQCQSP 416
            |.:.:                     :.|              |||.|
  Fly  1475 ATLSV---------------------REN--------------AAEVQ----------------- 1487

Mouse   417 TNYLQGLNGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 481
                        :..|...:.||:..|:||....|.|.|.|.|.|.|:|::....|:||||:.|.
  Fly  1488 ------------LVPPRILRFLQSGKATEGSSFQFACVVAGVPLPTVQWFKNDKCIDDSPDYVIS 1540

Mouse   482 QKKPRSMAEPEEICTLVIAEVFSEDSGCFTCTASNKYGTVSSIAQLDVRGNEDISDNGALHSANS 546
            .....:        ||...|||.||...:||:||
  Fly  1541 YNNGEA--------TLKFEEVFLEDDAVYTCSAS------------------------------- 1566

Mouse   547 TTNPAVAEHQPSPLNPQPLSEEQPPKPKLEGVLVNHNEPRSS--SRIGLRVHFNLPEDDKDMEAS 609
              |||..||..:.|..:||...:.|..|:         |.|:  :|:|.::         .:||.
  Fly  1567 --NPAGIEHCSASLIVEPLEPTELPSFKV---------PLSNAMARVGQKI---------KLEAI 1611

Mouse   610 SGSGAANTSQTRPNSFPERFNGQEARIPEPSSPIKEPPPVLAKPKLDSTQLQQLHNQVLLEQQQL 674
            .|.                       ||.|                              |...|
  Fly  1612 VGG-----------------------IPRP------------------------------EVYWL 1623

Mouse   675 QNTSPSSPKESLHMSALNSAPPAVTISSKQVKGPAPQMFNLARPKHFFPASSTSTATVSPSSSPV 739
            .|..|..|::|.:...      .||:.       .||.:                    |:.:..
  Fly  1624 HNGKPFQPRDSKYEYG------RVTLI-------IPQAY--------------------PNDAGS 1655

Mouse   740 FTLSNTPQTIQRTVSKESLLMAHPSTQGRSPGGLSIQNEPAPPSPAEPAAP-PTAAYSIPSGNQF 803
            :.||      .:.::.|:....:...:||.|...|.....:...|.:||.. |....||..|...
  Fly  1656 YVLS------AKNLAGEAYTSCNVIVKGRLPNETSDSEMASDIEPIKPAVHLPLKDVSIFEGKPV 1714

Mouse   804 QPHCVSPTPVSPTGRIQNPVAFLSSVLPSLPSIPPTNAMGLPKSAPSVPSQGLMKKTTKAPQAV- 867
            :..||                                .:|.|:                 |:.:
  Fly  1715 RLDCV--------------------------------IVGQPE-----------------PEVIW 1730

Mouse   868 --SDDYIRETKNSVILDLGKKVNFGDVRSHQQE---YKISSFEQRLMNEIEFRLERTPVDESDD- 926
              ::..::|:.:..:|..|.:.:......:|::   ||:.:............|:.||:::::.
  Fly  1731 YHNERPVKESADVQLLFQGDRCSLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQAEPA 1795

Mouse   927 ---EIEHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHC 988
               :.|...:|  |...|.|::.|......||..|....:..|.......||...|:: :.::..
  Fly  1796 TRAQAERQSLP--KDSQPKFERLLSDVLADEGEQVVLEVQASGDQPLTAQWFLTNKEL-QLDQRI 1857

Mouse   989 KMRREGD-GTCSLHIESTHGDDDGNYTIMAANPQGRISCSGHLMVQGLPIRSRLSPALSHRGRSR 1052
            ..:.:.: |...|.:.:..|||.|.||:...||.|...|..||:|:.:           :...:|
  Fly  1858 TTQSDSELGVFKLILNNVSGDDKGVYTVKVTNPAGDAKCFSHLIVKSV-----------NAPENR 1911

Mouse  1053 MQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1117
            ...:....:.||...|.|.:...|.......:.:.:|.|.|.|.|::.|..|.|||   ..|..|
  Fly  1912 RSSQSSVEIIERHQCPEFKELFSDKQGEIDEVIKFECIVKGKPTPKVHWFFNDQPV---HGHNFL 1973

Mouse  1118 VRETGVHSLL-IDPLTQRDAGTYTCVATNKTGQNS-------------FSLELTVVAKE------ 1162
            |..:|...:| |..||....|..:|||.|:.|:.:             .|.::..|::|
  Fly  1974 VSTSGERQVLTIQKLTHDAVGKISCVAENEAGKATCVAFLNIRGSGLPASSDVQTVSQEHNTESS 2038

Mouse  1163 ---VKK----------------------------------------------------------- 1165
               :||
  Fly  2039 RVTIKKQTFTTTSTSQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVESHHYQELHKSKEM 2103

Mouse  1166 -APVILEK----LQNSG--------VPEGHPVR------------LEGRVI-------------G 1192
             :|.:.:|    :|:||        :|:. |.|            |.|:::             |
  Fly  2104 SSPTVQQKSFSFIQSSGANGQSAVAIPDS-PTRLRREIAPRFTTPLSGKIVDQGADVSMEAIYDG 2167

Mouse  1193 MP-PPVFYWKKDNETIPFTRERISMHQDTTGYVCLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1256
            .| |.:...|...:.......|||   :....|.:.::.....|||.|.::|.|..|..:.||.|
  Fly  2168 FPSPEIKVEKNGGQLFEDAHTRIS---NKCNRVTIELKQVGVGDAGRYAVTASNTVGQSTSTADL 2229

Mouse 1257 1256
Fly 2230 2229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mypn	NP_892037.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..60		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..145		16/89 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..204		4/37 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..266		9/43 (21%)
		I-set	267..353	CDD:254352	29/85 (34%)
		Ig	284..353	CDD:143165	23/68 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..392		1/32 (3%)
		I-set	432..529	CDD:254352	31/96 (32%)
		Ig	449..526	CDD:143165	25/76 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	535..652		20/118 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..704		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..747		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..814		13/52 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..865		2/24 (8%)
		I-set	941..1032	CDD:254352	24/91 (26%)
		Ig	958..1027	CDD:143165	16/69 (23%)
		I-set	1068..1158	CDD:254352	28/103 (27%)
		Ig	1086..1155	CDD:143165	25/82 (30%)
		I-set	1167..1256	CDD:254352	27/126 (21%)
		Ig	1184..1258	CDD:299845	21/99 (21%)
zormin	NP_001261317.1	SPEC	126..332	CDD:238103
		SPEC	<504..641	CDD:295325
		COG1340	960..1298	CDD:224259	33/185 (18%)
		RILP-like	<1190..1315	CDD:304877	20/124 (16%)
		MAP7	1233..1365	CDD:283355	21/153 (14%)
		I-set	1390..1479	CDD:254352	32/93 (34%)
		IGc2	1403..1469	CDD:197706	23/65 (35%)
		I-set	1491..1580	CDD:254352	37/129 (29%)
		IGc2	1504..1570	CDD:197706	29/106 (27%)
		I-set	1589..1675	CDD:254352	26/195 (13%)
		Ig	1605..1675	CDD:299845	20/170 (12%)
		I-set	1702..1786	CDD:254352	16/132 (12%)
		Ig	1713..1786	CDD:299845	12/121 (10%)
		I-set	1811..1902	CDD:254352	24/91 (26%)
		Ig	1828..1892	CDD:143165	15/64 (23%)
		I-set	1927..2015	CDD:254352	27/90 (30%)
		IGc2	1940..2005	CDD:197706	23/67 (34%)
		I-set	2142..2231	CDD:254352	20/91 (22%)
		Ig	2158..2231	CDD:299845	18/75 (24%)
		I-set	2238..2325	CDD:254352
		Ig	2254..2324	CDD:299845
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000