DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TAF5 and taf5

DIOPT Version :9

Sequence 1:	NP_008882.2	Gene:	TAF5 / 6877	HGNCID:	11539	Length:	800	Species:	Homo sapiens
Sequence 2:	NP_001135586.1	Gene:	taf5 / 100216139	XenbaseID:	XB-GENE-1004611	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	818	Identity:	611/818 - (74%)
Similarity:	675/818 - (82%)	Gaps:	59/818 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGDGGTPK 65
            |||:.:| ..|.||.|||         ..|.|.....|..:       ||..|.    |:|..|.
Frog     1 MAAVPDE-ASVVVKAEPE---------VQDEAKPDISGCVD-------GNAQAL----GNGAPPS 44

Human    66 PTVAVSAAAPAGAAPVP---AAAPDAGAP------HDRQTLLAVLQFLRQSKLREAEEALRREAG 121
            |      ::|..|.|||   ||.|.|.||      .||||||||||:|::.||:::.:.|.||:|
Frog    45 P------SSPQAAPPVPPGVAAPPAAAAPAPGSDASDRQTLLAVLQYLKKRKLKDSADILLRESG 103

Human   122 LL--EEAVAGSGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATV---VSGSASGP 181
            |.  :|.:|.:....:...||....:.|||||              :||:|:.:   ..|:||..
Frog   104 LFDSDELLALTSLSPDRAGAGDGADTTLLSRV--------------SGAAGSDISASAGGAASSS 154

Human   182 AAPGKVGSVAV----EDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLFYP 242
            |:....|.|.:    :||||||||||||.|||||.:|||||||||.|||..||||||||||||||
Frog   155 ASSACAGKVTLNNGPQDQPDVSAVLSAYTQQGDPALYEEYYSGLKRFIESVLDCHRAELSQLFYP 219

Human   243 LFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDFRTSKFVL 307
            |||||||||||||||.:||||||||||||||||:||||:|:||:||.||.||||:||||||||||
Frog   220 LFVHMYLELVYNQHEQKAKSFFEKFHGDQECYYEDDLRILASLSKKGHMMGNETILDFRTSKFVL 284

Human   308 RISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLAGEAKREANKSKV 372
            ||||||||||||||||:||||||:||||||||||||||||||||||||||||:|||||||||:|:
Frog   285 RISRDSYQLLKRHLQERQNNQIWSIVQEHLYIDIFDGMPRSKQQIDAMVGSLSGEAKREANKAKI 349

Human   373 FFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLPELKDSDK 437
            ||||||||||||||||||||.|||||||||||||||::|||||||||||||||||||||||||||
Frog   350 FFGLLKEPEIEVPLDDEDEEVENEEGKPKKKKPKKDNVGSKSKKQDPNAPPQNRIPLPELKDSDK 414

Human   438 LDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPK 502
            |||||.||||.||||||.|.|||||||||||||||||||||||||||||||||||||||||:|||
Frog   415 LDKIMIMKETAKRVRLGQDSLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSLTPK 479

Human   503 KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTV 567
            ||||||.|||||:||||||||||||||||::||:|:|||||||||..|||||||||||||||||:
Frog   480 KLRSVKSASDLSIIDKESDDVLERIMDEKSSSEMKVLYGHSGPVYATSFSPDRNYLLSSSEDGTI 544

Human   568 RLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
            ||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||.|
Frog   545 RLWSLQTFTCLVAYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVIC 609

Human   633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
            |||||||||:||||.||||||||||||||||||||||||||||.|:|||:||||||:||||||||
Frog   610 TRFHPNSNYIATGSTDRTVRLWDVLNGNCVRIFTGHKGPIHSLAFTPNGKFLATGASDGRVLLWD 674

Human   698 IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLP 762
            ||||||||||||||:||.:||||||||||:|.||||||||||.:||||||:|||||::.||||..
Frog   675 IGHGLMVGELKGHTNTVYALRFSRDGEILSSVSMDNTVRLWDTVKAFEDLDTDDFTSSAGHINFH 739

Human   763 ENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAYSPQ 800
            ||||:|||||:|||||||:|||||||||:||||||:||
Frog   740 ENSQDLLLGTFMTKSTPVIHLHFTRRNLLLAAGAYTPQ 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAF5	NP_008882.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74		20/72 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..189		7/38 (18%)
		TFIID_NTD2	209..337	CDD:367963	111/127 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..438		50/53 (94%)
		WD 1	468..507		37/38 (97%)
		WD40	472..739	CDD:238121	243/266 (91%)
		WD40 repeat	473..541	CDD:293791	60/67 (90%)
		WD 2	541..580		35/38 (92%)
		WD40 repeat	547..583	CDD:293791	31/35 (89%)
		WD 3	583..624		40/40 (100%)
		WD40 repeat	588..624	CDD:293791	35/35 (100%)
		WD 4	625..666		37/40 (93%)
		WD40 repeat	631..666	CDD:293791	31/34 (91%)
		WD 5	667..706		34/38 (89%)
		WD40 repeat	672..708	CDD:293791	31/35 (89%)
		WD 6	709..748		31/38 (82%)
		WD40 repeat	714..756	CDD:293791	33/41 (80%)
taf5	NP_001135586.1	TAF5_NTD2	188..320	CDD:176269	115/131 (88%)
		WD40	<426..716	CDD:225201	264/289 (91%)
		WD40	449..719	CDD:238121	245/269 (91%)
		WD40 repeat	450..507	CDD:293791	53/56 (95%)
		WD40 repeat	524..560	CDD:293791	31/35 (89%)
		WD40 repeat	565..601	CDD:293791	35/35 (100%)
		WD40 repeat	608..643	CDD:293791	31/34 (91%)
		WD40 repeat	649..685	CDD:293791	31/35 (89%)
		WD40 repeat	691..737	CDD:293791	35/45 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I11707
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5064
Inparanoid	1	1.050	1200	1.000	Inparanoid score	I2233
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52000
OrthoDB	1	1.010	-	-		D103208at7742
OrthoFinder	1	1.000	-	-		FOG0003655
OrthoInspector	1	1.000	-	-		oto150785
Panther	1	1.100	-	-	LDO	PTHR19879
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1472
SonicParanoid	1	1.000	-	-		X3022
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.110