DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TACR3 and TkR86C

DIOPT Version :9

Sequence 1:	NP_001050.1	Gene:	TACR3 / 6870	HGNCID:	11528	Length:	465	Species:	Homo sapiens
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	153/467 - (32%)
Similarity:	240/467 - (51%)	Gaps:	80/467 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    44 LLDQAGNLSSSPSALGL--PVASPAPSQ----PWANLTNQFVQPSWRIALWSLAYGVVVAVAVLG 102
            ::|...||.|...|...  ....|:|::    ||...|           :|::.:|:::.||:.|
  Fly    47 IIDNRDNLESINEAKDFLTECLFPSPTRPYELPWEQKT-----------IWAIIFGLMMFVAIAG 100

Human   103 NLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPIT 167
            |.||:||:..|:.|||||||||:||:.:|..|::.|.:.|||:.|:|:|.||:.||...||....
  Fly   101 NGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANV 165

Human   168 AVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVM----- 227
            .|..|::::.||:.|||:||:.|||.|.|....:|::..||.|:.:|:.|..|||.....
  Fly   166 TVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNG 230

Human   228 PGRTLCFVQWPEG----PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYH 288
            ..||:||:.||:|    ....:.|::|:::|.|..|:::|.|.|:::|..|||....|:..|:..
  Fly   231 KSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQM 295

Human   289 EQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNP 353
            |.:|:|||||:|.|.:|..|||||||||::||......|:...||:|.:||..:|||||:.|.||
  Fly   296 ESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNP 360

Human   354 IIYCCLNKRFRAGFKRAFRWC-----------PFIKVSSYD------------------------ 383
            :||..:|||||..|:|....|           |..::::.:
  Fly   361 LIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPTT 425

Human   384 ------------------ELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKR-A 429
                              :|.|.....||.:.|:..|.::.:..|:......|..|.|.|::| |
  Fly   426 QTLLAVLAQTLTQPKPQTQLLLSHHSPHPTQPSAAETKSQWKRSTMETQIQQAPVTSSCREQRSA 490

Human   430 TPRDPSFNGCSR 441
            ..:.|..:|.:|
  Fly   491 QQQQPPGSGTNR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TACR3	NP_001050.1	7tmA_NKR_NK3R	86..367	CDD:320669	123/289 (43%)
		TM helix 1	87..113	CDD:320669	10/25 (40%)
		TM helix 2	120..146	CDD:320669	13/25 (52%)
		TM helix 3	158..188	CDD:320669	11/29 (38%)
		TM helix 4	199..220	CDD:320669	6/20 (30%)
		TM helix 5	244..273	CDD:320669	9/28 (32%)
		TM helix 6	292..322	CDD:320669	20/29 (69%)
		TM helix 7	335..360	CDD:320669	13/24 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..465		9/28 (32%)
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	122/283 (43%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	112/262 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105137
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3520
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.710