DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TACR1 and TkR99D

DIOPT Version :9

Sequence 1:	NP_001049.1	Gene:	TACR1 / 6869	HGNCID:	11526	Length:	407	Species:	Homo sapiens
Sequence 2:	NP_001263092.1	Gene:	TkR99D / 43551	FlyBaseID:	FBgn0004622	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	326	Identity:	144/326 - (44%)
Similarity:	212/326 - (65%)	Gaps:	9/326 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    25 FVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVN 89
            ||.|.|:.|||:..:..:|:.:..||::|:||::..||||||||||:|||:.|:|.:::.|...|
  Fly    94 FVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFN 158

Human    90 FTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVI 154
            :.|.:.::|.:|.||||...|..:.::.||::::.|::.|||:|||.|||||:|......:..||
  Fly   159 YYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVI 223

Human   155 WVLALLLAFPQGYYSTTETMP-----SRVVCMIEWPEHP--NKIYEKVYHICVTVLIYFLPLLVI 212
            |:.:.|::.|......||.:|     :|.||..|||:.|  :...|.:|:|.:.:|.||||::.:
  Fly   224 WLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSM 288

Human   213 GYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDL 277
            ...|:.|||.||.|:..|:.:.|..|.|.:||:|||||||||..|||||||||.:|::....|.:
  Fly   289 TVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAI 353

Human   278 YLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAG--DYEGLEMKSTR 340
            ....|||::||||.|||||::||||||||.:|.|||.|||..||.|.|:..|  .:...|..::|
  Fly   354 TEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSR 418

Human   341 Y 341
            |
  Fly   419 Y 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TACR1	NP_001049.1	7tmA_NK1R	33..316	CDD:320668	129/289 (45%)
		TM helix 1	35..59	CDD:320668	7/23 (30%)
		TM helix 2	68..90	CDD:320668	9/21 (43%)
		TM helix 3	106..128	CDD:320668	5/21 (24%)
		TM helix 4	149..165	CDD:320668	4/15 (27%)
		TM helix 5	194..217	CDD:320668	7/22 (32%)
		TM helix 6	247..269	CDD:320668	17/21 (81%)
		TM helix 7	284..309	CDD:320668	18/24 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407
TkR99D	NP_001263092.1	7tm_4	113..396	CDD:304433	128/282 (45%)
TkR99D	NP_001263092.1	7tm_1	118..381	CDD:278431	118/262 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1855
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2456
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45276
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		otm41142
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3520
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870