Protein Alignment TACR1 and CCHa1-R

DIOPT Version :10

• Sequence 1: NP_001049.1
• Gene: TACR1 / 6869
• HGNCID: 11526
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 469
• Identity: 113/469 - (24%)
• Similarity: 203/469 - (43%)
• Gaps: 106/469 - (22%)

Human     3 NVLPVDSDLSPNISTNTS---------EPNQFVQPAWQIVL-------W---------------- 35
            |::.:::||:.||..:||         .|| ..:..|.:.:       |
  Fly     4 NLVSMETDLAMNIGLDTSGEAPTALPPMPN-VTETLWDLAMVVSQSTQWPLLDTGSSENFSELVT 67

Human    36 -----------------AAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAE----- 78
                             ...:.:|.|..|:||..::.:.|:.::||.|.|.::::||.|:
  Fly    68 TETPYVPYGRRPETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVII 132

Human    79 ASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQP--- 140
            .::...:||....|     |.||.|.|....|....::..|::::||::.|||.||:.||:.
  Fly   133 TTVPLASTVYTVEY-----WPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHA 192

Human   141 ----RLSATATKVVICVIWVLALLLAFPQGYYSTTETM----PSRVVCMIEWPEHPNKIYEKVYH 197
                |.:...|......||:||:|...|....|..:.:    .|.|:| ..:||.....|.|...
  Fly   193 HGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHLGINEKSIVIC-YPYPEEWGINYAKSMV 256

Human   198 ICVTVLIYFLPLLVIGYAYTVVGITL-WASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICW 261
            :...::.|.:||:||...|.::.:.| :::.:||:..... .||.|:|||...::..|..|.||:
  Fly   257 LLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAV-RQVRARRKVAVTVLAFVVIFGICF 320

Human   262 LPFHIFFLLPYINP---DLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCC 323
            ||:|:|||..|..|   |.| ..|...:.:....::.:::..||:....::..||..| :.:..|
  Fly   321 LPYHVFFLWFYFWPTAQDDY-NAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRKHF-NRYLFC 383

Human   324 PFISA-----GDYE--------GLEMKSTRYLQTQGSVYKVS----RL-ETTISTVVGAHEEEPE 370
            ...|.     |.::        .|...:::..|::.|.|:.:    || ||||:|:       |.
  Fly   384 RGASGRRKKRGQHDTFCMHRDTSLTSTASKRFQSRHSCYQSTIRSCRLQETTITTL-------PN 441

Human   371 DGPK--ATPSSLDL 382
            .|.:  |..|:::|
  Fly   442 GGNQNGANISAVEL 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TACR1	NP_001049.1	7tmA_NK1R	33..316	CDD:320668	83/342 (24%)
		TM helix 1	34..60	CDD:320668	7/65 (11%)
		TM helix 2	67..93	CDD:320668	6/30 (20%)
		TM helix 3	105..135	CDD:320668	9/29 (31%)
		TM helix 4	146..167	CDD:320668	7/20 (35%)
		TM helix 5	193..222	CDD:320668	7/28 (25%)
		TM helix 6	241..271	CDD:320668	14/29 (48%)
		TM helix 7	284..309	CDD:320668	2/24 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..407		5/21 (24%)
CCHa1-R	NP_611241.2	7tmA_Bombesin_R-like	82..377	CDD:320593	82/302 (27%)
		TM helix 1	83..109	CDD:320593	6/25 (24%)
		TM helix 2	116..142	CDD:320593	5/25 (20%)
		TM helix 3	154..184	CDD:320593	9/29 (31%)
		TM helix 4	201..221	CDD:320593	6/19 (32%)
		TM helix 5	252..277	CDD:320593	7/24 (29%)
		TM helix 6	300..330	CDD:320593	14/29 (48%)
		TM helix 7	345..370	CDD:320593	2/24 (8%)