Protein Alignment TACR1 and CCHa2-R

DIOPT Version :10

• Sequence 1: NP_001049.1
• Gene: TACR1 / 6869
• HGNCID: 11526
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_001356958.1
• Gene: CCHa2-R / 35535
• FlyBaseID: FBgn0033058
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 351
• Identity: 89/351 - (25%)
• Similarity: 156/351 - (44%)
• Gaps: 28/351 - (7%)

Human    27 QPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFT 91
            :|...||  ...||:|.:..|:||..::.|...|:.||.:.|.::::||.|:..:......|...
  Fly    66 RPETYIV--TVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATI 128

Human    92 YAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWV 156
            ......|.:....|:...||...::..|::::||::.:||.||::||:...:...|.....:||:
  Fly   129 VYTQESWPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAVMIWI 193

Human   157 LALLLAFPQGYYS---------TTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVI 212
            ||:||..|...:|         .|..|...|......||     |.|.......::.|.|||.:|
  Fly   194 LAILLGMPSVLFSDIKSYPVFTATGNMTIEVCSPFRDPE-----YAKFMVAGKALVYYLLPLSII 253

Human   213 GYAYTVVG--ITLWASEIPGD-SSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYIN 274
            |..|.::.  :.:.|..:||: .|.:...|..|:..|.:|::..|..|.||:.|:|:|.|..:..
  Fly   254 GALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELWYHFY 318

Human   275 P--DLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMK 337
            |  :....:|...:.:.....:..::..||:...|::..||..| :.:.||..:....:  |...
  Fly   319 PTAEEDFDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHF-NRYLCCICVKRQPH--LRQH 380

Human   338 STRYLQTQGSVYKVSRLETTISTVVG 363
            ||    ..|.:...|.:....||.||
  Fly   381 ST----ATGMMDNTSVMSMRRSTYVG 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TACR1	NP_001049.1	7tmA_NK1R	33..316	CDD:320668	75/296 (25%)
		TM helix 1	34..60	CDD:320668	7/25 (28%)
		TM helix 2	67..93	CDD:320668	5/25 (20%)
		TM helix 3	105..135	CDD:320668	9/29 (31%)
		TM helix 4	146..167	CDD:320668	8/20 (40%)
		TM helix 5	193..222	CDD:320668	8/30 (27%)
		TM helix 6	241..271	CDD:320668	11/29 (38%)
		TM helix 7	284..309	CDD:320668	3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..407		89/351 (25%)
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	76/298 (26%)
		TM helix 1	71..97	CDD:320593	9/27 (33%)
		TM helix 2	104..130	CDD:320593	5/25 (20%)
		TM helix 3	142..172	CDD:320593	9/29 (31%)
		TM helix 4	182..202	CDD:320593	7/19 (37%)
		TM helix 5	234..259	CDD:320593	8/24 (33%)
		TM helix 6	285..315	CDD:320593	11/29 (38%)
		TM helix 7	330..355	CDD:320593	3/24 (13%)