DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADAM17 and kuz

DIOPT Version :9

Sequence 1:	NP_003174.3	Gene:	ADAM17 / 6868	HGNCID:	195	Length:	824	Species:	Homo sapiens
Sequence 2:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster

Alignment Length:	935	Identity:	211/935 - (22%)
Similarity:	341/935 - (36%)	Gaps:	313/935 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    33 EKLDSLLSDYDILSLSNIQ---QHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNF 94
            |:|:..:|.|:.|:..:..   .|:..:|.:....:|.  |.|::..|.|.|.|......||.
  Fly    35 ERLNEYISHYETLNYDHEHIRASHNRARRSVTKDQYVH--LKFASHGRDFHLRLKRDLNTFSN-- 95

Human    95 KVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIE--------- 150
            |:...|.|...:  |.....:.|.|:|:.:|.|...|.:.....:|.|:...|.:|
  Fly    96 KLDFYDSKGPID--VSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFPTN 158

Human   151 ----------------------------------------------------------------- 150

  Fly   159 RTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEYTE 223

Human   151 ----------PLWRFVNDTKDK--------RMLVYKS---------------------------- 169
                      |...:..|.|::        ..::||.
  Fly   224 SSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWM 288

Human   170 EDIKN--VSRLQSPKVCGYLKVDNEELLPKGLVDRE----PPE---------------------- 206
            |:|:|  |..|..|....|.|:..::|..|....::    ||:
  Fly   289 ENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANF 353

Human   207 ------------------------ELVH-RVKRRAD---------------PDPMKNTCKLLVVA 231
                                    :||| ||:|..|               .:..||||.|.:..
  Fly   354 AEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQT 418

Human   232 DHRFYRYMGRG------------EEST---TTNYLIELIDRVDDIYRNTSWD-NAGFKGYGIQIE 280
            |...:|::..|            :|.|   .|:.:...:..|:.|||||.:| ....:....:::
  Fly   419 DPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQ 483

Human   281 QIRILKSPQEVKPGEKHYN-MAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFD 344
            :|:|    .:.......|| ...::.||.   .||...|...|.   |:.|..|||::|||:||.
  Fly   484 RIKI----DDDSACRNSYNGPHNAFCNEH---MDVSNFLNLHSL---EDHSDFCLAYVFTYRDFT 538

Human   345 MGTLGLAYVGSPRANSHGGVCP--KAYYSPVG------KKNIYLNSGLTSTKNYGKTILTKEADL 401
            .||||||:|.| .:.:.||:|.  |.|...||      |::  ||:|:.:..||...:..|.:.|
  Fly   539 GGTLGLAWVAS-ASGASGGICEKYKTYTETVGGQYQSTKRS--LNTGIITFVNYNSRVPPKVSQL 600

Human   402 VTTHELGHNFGAEHD-PDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIE-- 463
            ...||:|||||:.|| |.   ||.|. ...|.|:|:..|.|||..||..||.||.::|...::
  Fly   601 TLAHEIGHNFGSPHDYPQ---ECRPG-GLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVL 661

Human   464 --SKAQECFQERSNKVCGNSRVDEGEECDPGIMYLN----NDTCC------------NSD---CT 507
              :..::||:......|||..|:.|||||.|   .|    .|.||            ||.   ||
  Fly   662 VGNTKRDCFKASEGAFCGNKIVESGEECDCG---FNEEECKDKCCYPRLISEYDQSLNSSAKGCT 723

Human   508 LKEGVQCSDRNSPCC--KNCQF--ETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCL 568
            .:...|||....|||  .:|.|  .:..:||:|  ...|...|.|.|.::|||.|.:.:|.|:|.
  Fly   724 RRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE--ETECSWSSTCNGTTAECPEPRHRDDKTMCN 786

Human   569 D------LGKCKDGKC--------------IPFCEREQQLESCACNETDNSCKVCCRDLSGRCVP 613
            :      .|:|....|              :|...: ::|...||.:.:::.  .||..|.....
  Fly   787 NGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSK-RKLCDLACQDGNDTS--TCRSTSEFADK 848

Human   614 YVDAEQKNLFLRKGKPCT--VGFCDMNGKCEK--------RVQDVIERFWDFIDQLSINTFGKFL 668
            | :.::..:.|:.|.||.  .|:||:..||..        |:::::      :::.::.|..:::
  Fly   849 Y-NIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLL------LNRKTLQTVAEWI 906

Human   669 ADNIVGSVLVFSLIFWIPFSILVHC 693
            .||.. .|::..:.|.:.....:.|
  Fly   907 VDNWY-LVVLMGVAFIVVMGSFIKC 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADAM17	NP_003174.3	Pep_M12B_propep	56..152	CDD:307618	24/179 (13%)
		Cysteine switch. /evidence=ECO:0000250	182..189		1/6 (17%)
		ZnMc_TACE_like	223..477	CDD:239798	89/283 (31%)
		DISIN	484..560	CDD:214490	33/98 (34%)
		ADAM17_MPD	581..641	CDD:318829	14/61 (23%)
		Crambin-like	603..671		15/77 (19%)
		SH3-binding. /evidence=ECO:0000255	731..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..824
		SH3-binding. /evidence=ECO:0000255	741..748
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	89/283 (31%)
		Reprolysin_2	450..659	CDD:290307	78/225 (35%)
		Disintegrin	684..776	CDD:278623	32/96 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920