Sequence 1: | NP_003174.3 | Gene: | ADAM17 / 6868 | HGNCID: | 195 | Length: | 824 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_477187.1 | Gene: | kuz / 34772 | FlyBaseID: | FBgn0259984 | Length: | 1238 | Species: | Drosophila melanogaster |
Alignment Length: | 935 | Identity: | 211/935 - (22%) |
---|---|---|---|
Similarity: | 341/935 - (36%) | Gaps: | 313/935 - (33%) |
- Green bases have known domain annotations that are detailed below.
Human 33 EKLDSLLSDYDILSLSNIQ---QHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNF 94
Human 95 KVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIE--------- 150
Human 151 ----------------------------------------------------------------- 150
Human 151 ----------PLWRFVNDTKDK--------RMLVYKS---------------------------- 169
Human 170 EDIKN--VSRLQSPKVCGYLKVDNEELLPKGLVDRE----PPE---------------------- 206
Human 207 ------------------------ELVH-RVKRRAD---------------PDPMKNTCKLLVVA 231
Human 232 DHRFYRYMGRG------------EEST---TTNYLIELIDRVDDIYRNTSWD-NAGFKGYGIQIE 280
Human 281 QIRILKSPQEVKPGEKHYN-MAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFD 344
Human 345 MGTLGLAYVGSPRANSHGGVCP--KAYYSPVG------KKNIYLNSGLTSTKNYGKTILTKEADL 401
Human 402 VTTHELGHNFGAEHD-PDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIE-- 463
Human 464 --SKAQECFQERSNKVCGNSRVDEGEECDPGIMYLN----NDTCC------------NSD---CT 507
Human 508 LKEGVQCSDRNSPCC--KNCQF--ETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCL 568
Human 569 D------LGKCKDGKC--------------IPFCEREQQLESCACNETDNSCKVCCRDLSGRCVP 613
Human 614 YVDAEQKNLFLRKGKPCT--VGFCDMNGKCEK--------RVQDVIERFWDFIDQLSINTFGKFL 668
Human 669 ADNIVGSVLVFSLIFWIPFSILVHC 693 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
ADAM17 | NP_003174.3 | Pep_M12B_propep | 56..152 | CDD:307618 | 24/179 (13%) |
Cysteine switch. /evidence=ECO:0000250 | 182..189 | 1/6 (17%) | |||
ZnMc_TACE_like | 223..477 | CDD:239798 | 89/283 (31%) | ||
DISIN | 484..560 | CDD:214490 | 33/98 (34%) | ||
ADAM17_MPD | 581..641 | CDD:318829 | 14/61 (23%) | ||
Crambin-like | 603..671 | 15/77 (19%) | |||
SH3-binding. /evidence=ECO:0000255 | 731..738 | ||||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 732..824 | ||||
SH3-binding. /evidence=ECO:0000255 | 741..748 | ||||
kuz | NP_477187.1 | ZnMc_TACE_like | 410..677 | CDD:239798 | 89/283 (31%) |
Reprolysin_2 | 450..659 | CDD:290307 | 78/225 (35%) | ||
Disintegrin | 684..776 | CDD:278623 | 32/96 (33%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D162519at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.920 |