Protein Alignment TACR2 and tacr3

DIOPT Version :10

• Sequence 1: NP_001048.2
• Gene: TACR2 / 6865
• HGNCID: 11527
• Length: 398
• Species: Homo sapiens
• Sequence 2: XP_002934808.1
• Gene: tacr3 / 100486525
• XenbaseID: XB-GENE-985728
• Length: 431
• Species: Xenopus tropicalis
• Alignment Length: 346
• Identity: 186/346 - (53%)
• Similarity: 244/346 - (70%)
• Gaps: 10/346 - (2%)

Human     8 TEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFI 72
            |:.|:|| |.::     .|..|.|::|||:.||.::|.|||.||.|||||||||:|||||||||:
 Frog    30 TQRNVSS-PVAH-----KFVQPPWRIALWSLAYGSMVAVAVFGNIIVIWIILAHKRMRTVTNYFL 88

Human    73 VNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVH 137
            ||||.:|..|||||...||:||.||.||||.|:|.|.|.||||::|.|||||:|||.||||||:.
 Frog    89 VNLAFSDASMAAFNTLVNFIYALHNEWYFGEAYCRFHNFFPITSIFASIYSMSAIAVDRYMAIID 153

Human   138 PFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVI 202
            |.:|||||.|||.||..||:.|:.||.|||.||.:.:.:..|.|::.||   |....|.|..:::
 Frog   154 PLKPRLSATSTKVVIGSIWIFAILLAFPQCLYSKIRVTRTRTLCMLVWP---GKDERLTYQFILV 215

Human   203 ALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYH 267
            .|:|.|||.||.|.|:::|:|||...:||..:...: ..|:|.:|.||.|::||:||||||||||
 Frog   216 LLVYVLPLIVMGVTYTIVGITLWGGEIPGDTSDKYH-EQLRAKRKVVKMMIVVVVTFAICWLPYH 279

Human   268 LYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTK 332
            ::|:..:....:...|:|||:|||:|||||||||||||||||||.|||:||:.|||.||::..:.
 Frog   280 IFFLADALDIKLDRWKYIQQIYLAIFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIEVSS 344

Human   333 EDKLELTPTTSLSTRVNRCHT 353
            .|:|||..|....||.:..:|
 Frog   345 YDELELKSTRFHPTRQSSLYT 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TACR2	NP_001048.2	7tmA_SKR_NK2R	34..318	CDD:320670	163/283 (58%)
		TM helix 1	35..61	CDD:320670	17/25 (68%)
		TM helix 2	68..94	CDD:320670	16/25 (64%)
		TM helix 3	106..136	CDD:320670	21/29 (72%)
		TM helix 4	147..168	CDD:320670	12/20 (60%)
		TM helix 5	194..223	CDD:320670	12/28 (43%)
		TM helix 6	243..273	CDD:320670	18/29 (62%)
		TM helix 7	286..311	CDD:320670	22/24 (92%)
tacr3	XP_002934808.1	7tm_GPCRs	50..330	CDD:475119	163/283 (58%)
		TM helix 1	52..76	CDD:320669	15/23 (65%)
		TM helix 2	85..107	CDD:320669	13/21 (62%)
		TM helix 3	123..145	CDD:320669	14/21 (67%)
		TM helix 4	166..182	CDD:320669	7/15 (47%)
		TM helix 5	208..231	CDD:320669	10/22 (45%)
		TM helix 6	261..283	CDD:320669	15/21 (71%)
		TM helix 7	298..323	CDD:320669	22/24 (92%)