Protein Alignment TACR2 and tacr1

DIOPT Version :10

• Sequence 1: NP_001048.2
• Gene: TACR2 / 6865
• HGNCID: 11527
• Length: 398
• Species: Homo sapiens
• Sequence 2: NP_001106489.1
• Gene: tacr1 / 100127678
• XenbaseID: XB-GENE-5835469
• Length: 407
• Species: Xenopus tropicalis
• Alignment Length: 380
• Identity: 188/380 - (49%)
• Similarity: 247/380 - (65%)
• Gaps: 19/380 - (5%)

Human    11 NISSGPES--NTTG------ITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTV 67
            |||....|  |:||      :..|..|:||:|||:.||..:|:|:|.||.||:||||||:|||||
 Frog     2 NISMQNSSICNSTGGNETCIVNPFLQPAWQIALWSIAYSIIVIVSVVGNIIVMWIILAHKRMRTV 66

Human    68 TNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRY 132
            ||||:||||.|:..|:|||...||.||.||.||:|..:|.|.|.|||:|:|.|||||||||.|||
 Frog    67 TNYFLVNLAFAEASMSAFNTVINFTYAIHNHWYYGLIYCKFHNFFPISAVFSSIYSMTAIALDRY 131

Human   133 MAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLY 197
            |||:||.:|||||.:|:.|||.||..|.|||.||.:::||........|.:.|||....|...:|
 Frog   132 MAIIHPLKPRLSATATRIVIAVIWGFAFALAFPQGYFATVEPTPDRVVCYMEWPESENRKFEKVY 196

Human   198 HLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQ--AMKKFVKTMVLVVLTFA 260
            .:::..|||||||.|:..:|:.||:|||...:||   ..::..|.|  |.:|.||.|::||.|||
 Frog   197 QVLLFGLIYFLPLLVIGCSYTFIGMTLWASEIPG---DSSDRYHEQVVAKRKVVKMMIVVVCTFA 258

Human   261 ICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCC 325
            |||||||:||:|..|..| ...||.||:||.:.||.|||||||||||||||.|||.||:..||.|
 Frog   259 ICWLPYHIYFLLQLFLPD-ESQKFYQQLYLGIMWLGMSSTMYNPIIYCCLNDRFRIGFKHVFRWC 322

Human   326 PWVTPTKEDKLELTPTTSLST-----RVNRCHTKETLFMAGDTAPSEATSGEAGR 375
            |::...:.:.||:..|..|.|     :::|..|..:..::.:...:|.|:..:.|
 Frog   323 PFIHAGEYEGLEMKSTRYLQTQSSMYKISRIETTVSSVLSANDEDAEETTKSSKR 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TACR2	NP_001048.2	7tmA_SKR_NK2R	34..318	CDD:320670	161/285 (56%)
		TM helix 1	35..61	CDD:320670	15/25 (60%)
		TM helix 2	68..94	CDD:320670	15/25 (60%)
		TM helix 3	106..136	CDD:320670	22/29 (76%)
		TM helix 4	147..168	CDD:320670	12/20 (60%)
		TM helix 5	194..223	CDD:320670	12/28 (43%)
		TM helix 6	243..273	CDD:320670	20/31 (65%)
		TM helix 7	286..311	CDD:320670	19/24 (79%)
tacr1	NP_001106489.1	7tmA_NK1R	33..315	CDD:320668	161/285 (56%)
		TM helix 1	34..60	CDD:320668	15/25 (60%)
		TM helix 2	67..93	CDD:320668	15/25 (60%)
		TM helix 3	105..135	CDD:320668	22/29 (76%)
		TM helix 4	146..167	CDD:320668	12/20 (60%)
		TM helix 5	193..222	CDD:320668	12/28 (43%)
		TM helix 6	241..271	CDD:320668	19/29 (66%)
		TM helix 7	283..308	CDD:320668	19/24 (79%)