Protein Alignment TACR2 and tacr2

DIOPT Version :10

• Sequence 1: NP_001048.2
• Gene: TACR2 / 6865
• HGNCID: 11527
• Length: 398
• Species: Homo sapiens
• Sequence 2: NP_001314788.1
• Gene: tacr2 / 100002125
• ZFINID: ZDB-GENE-090312-188
• Length: 376
• Species: Danio rerio
• Alignment Length: 382
• Identity: 213/382 - (55%)
• Similarity: 256/382 - (67%)
• Gaps: 28/382 - (7%)

Human     3 TCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTV 67
            |.|.::.:.:....:.|.|.|..|..|.||:||||.||..:|:::..||..||||||||:|||||
Zfish     4 TLDPLSSSLLYYDEDGNETSINLFEQPDWQVALWAIAYTLIVIISFIGNVTVIWIILAHKRMRTV 68

Human    68 TNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRY 132
            |||||||||.:|..||.||..||||||.||.||||..:|.|||.|||||||.|||||.|||.|||
Zfish    69 TNYFIVNLAFSDASMATFNTVFNFVYALHNDWYFGLGYCKFQNFFPITAMFSSIYSMAAIAVDRY 133

Human   133 MAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLY 197
            |||:||.:||||:.:||.:|..||.||.:||.|||:|::.......|.|:|.||:|.|||..|.|
Zfish   134 MAIIHPLKPRLSSTTTKLLIGVIWTVAFSLAFPQCYYASTKFYFPRTVCMVEWPDDYGGKHQLSY 198

Human   198 HLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQA-HGANLRHLQAMKKFVKTMVLVVLTFAI 261
            .:.||.|||.|||.||.|.||::|..||...:||..: |..|  .:||.:|.||.|::||.||||
Zfish   199 QIAVIILIYLLPLLVMLVTYSLVGQRLWGSEIPGEASDHYQN--QMQAKRKVVKMMIVVVTTFAI 261

Human   262 CWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCP 326
            ||||||:|||||||..|||...:|||||||:|||||||||||||||||||.|||||||.||:.||
Zfish   262 CWLPYHIYFILGSFNRDIYKQHYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGFRKAFQWCP 326

Human   327 WVTPTKEDKLEL-------------TPTTSLSTRVNRCHTKETLFMAGDTAPSEATS 370
            :|..::||.:||             |.|||:   |.|.|..|         |.:.||
Zfish   327 FVKISEEDNMELQHMRTFHMRRSYRTETTSV---VVRNHANE---------PEDTTS 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TACR2	NP_001048.2	7tmA_SKR_NK2R	34..318	CDD:320670	181/284 (64%)
		TM helix 1	35..61	CDD:320670	14/25 (56%)
		TM helix 2	68..94	CDD:320670	18/25 (72%)
		TM helix 3	106..136	CDD:320670	24/29 (83%)
		TM helix 4	147..168	CDD:320670	11/20 (55%)
		TM helix 5	194..223	CDD:320670	16/28 (57%)
		TM helix 6	243..273	CDD:320670	21/29 (72%)
		TM helix 7	286..311	CDD:320670	23/24 (96%)
tacr2	NP_001314788.1	7tm_GPCRs	35..318	CDD:475119	181/284 (64%)
		TM helix 1	37..61	CDD:320670	12/23 (52%)
		TM helix 2	70..92	CDD:320670	14/21 (67%)
		TM helix 3	108..130	CDD:320670	17/21 (81%)
		TM helix 4	151..167	CDD:320670	7/15 (47%)
		TM helix 5	196..219	CDD:320670	13/22 (59%)
		TM helix 6	249..271	CDD:320670	16/21 (76%)
		TM helix 7	286..311	CDD:320670	23/24 (96%)