DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SYT4 and Syt4

DIOPT Version :9

Sequence 1:	NP_065834.1	Gene:	SYT4 / 6860	HGNCID:	11512	Length:	425	Species:	Homo sapiens
Sequence 2:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	179/468 - (38%)
Similarity:	261/468 - (55%)	Gaps:	70/468 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    14 IPTVVGIFSAFGLVFTVSLFAWICCQ------RKSSKSNKTPPYKFV--------------HVLK 58
            :|.::|:.:|    ..:|..|.||.:      :|.|:.:.:.|::..              |.||
  Fly    16 VPAILGLTAA----AVLSSVACICARQMRLRNKKQSQHDASFPFQPTRRPTAVRSPSGQPPHYLK 76

Human    59 GVDIYPENLNSKKKFGADDKNEVKNKPAVPKN----------SLHLDLEKRDLNGN----FPKTN 109
            .   .|.....|:........:....|....|          :.|.:.:    |||    .....
  Fly    77 K---SPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQ----NGNQLTVVDGNG 134

Human   110 LKPGSPSDLENATPKLFLEGEKE-SVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVN 173
            ||....:.|.::..:....|... ::...||.:...||..::..||||::|.|.|..||.|.:|:
  Fly   135 LKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVS 199

Human   174 IKEARGLPAMDEQSMT--------------SDPYIKMTILPEKKHKVKTRVLRKTLDPAFDETFT 224
            |...||||.....|.|              :|||:|:.:||:|:|||||||:|.|.:|.:||.||
  Fly   200 IIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFT 264

Human   225 FYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIE---LSEGKMLMNREIIKRNVR-KS 285
            |||:....:|.::|||.||||||:||||:||||:.||:.||   :|:..:.:::||..|::: ::
  Fly   265 FYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSLKIRA 329

Human   286 SGRGELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTP 350
            .||||||||||:|.....||||:||||:||:.||:||:|||||:.|.:..:||:||||||||.|.
  Fly   330 QGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTL 394

Human   351 NAVFNELFVFDIP-CEG----LEDISVEFLVLDSERGSRNEVIGQLVLGAA-AEGTGGEHWKEIC 409
            :.||||.|.|||| .||    ||.:|:|.::||.:|.::|||||:|.||.. :..|...||.|:|
  Fly   395 SPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVC 459

Human   410 DYPRRQIAKWHVL 422
            :.||||||:||.|
  Fly   460 NSPRRQIAEWHKL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SYT4	NP_065834.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..93		2/29 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..147		4/20 (20%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	67/142 (47%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	81/141 (57%)
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	67/142 (47%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	81/141 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5601
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2845
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329810at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm40578
orthoMCL	1	0.900	-	-		OOG6_106708
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9815
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900