Protein Alignment SYT4 and Syt14

DIOPT Version :10

• Sequence 1: NP_065834.1
• Gene: SYT4 / 6860
• HGNCID: 11512
• Length: 425
• Species: Homo sapiens
• Sequence 2: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Alignment Length: 388
• Identity: 98/388 - (25%)
• Similarity: 168/388 - (43%)
• Gaps: 61/388 - (15%)

Human    83 NKPAVPKNSLHLDLEKRD-----------LNGNFPKTNLKPGSPSDLENATPKLFLEGEKESVSP 136
            |..|.||    ||.|:.:           :|.|..........||...|....||     ::...
  Fly   213 NVAAPPK----LDKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSNNNDDEPLF-----DTSDL 268

Human   137 ESLKSSTSLTSEEKQE---KLG--TLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKM 196
            .|:||...|...:::|   :.|  .|..||.|:...:...|::.:|:.||.:. ...|:...::|
  Fly   269 RSIKSDDLLVGVDQKEPAVQRGPIELELSLLYDAPMRKMTVHVMQAKNLPPLG-SGQTTHTQVRM 332

Human   197 TILPEKKHKVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPL 261
            .:||.||.|:||:: |...:|.:.|:|..:.:....:..:.|...:...:|..::.:|||..:..
  Fly   333 LMLPSKKQKLKTKI-RSGENPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSF 396

Human   262 SGIELS-EGKMLMNREIIKRNVRKSSGRG--------------------------ELLISLCYQS 299
            :.::|. |..:.:..|  .||.  |||.|                          |||:.|.|..
  Fly   397 ATVDLELETNLWLPLE--PRNT--SSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLGLSYNG 457

Human   300 TTNTLTVVVLKARHLPKSDVSGLSDPYVK-VNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIP 363
            .|..|:|.::|........::...|.||| |.:....:.||:.||.:::..||.:|.|.|.|.:.
  Fly   458 VTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQVA 522

Human   364 CEGLEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGG-EHWKEICDYPR-RQIAKWHVLCD 424
            ...|.|:::...|.......:||::|...||..:.|:.. .||.::|:.|: ..:|:||||.|
  Fly   523 LFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEMLARWHVLVD 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SYT4	NP_065834.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..93		4/9 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..147		4/19 (21%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	30/128 (23%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	42/163 (26%)
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	29/125 (23%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	41/137 (30%)