DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SYT4 and Sytbeta

DIOPT Version :9

Sequence 1:	NP_065834.1	Gene:	SYT4 / 6860	HGNCID:	11512	Length:	425	Species:	Homo sapiens
Sequence 2:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	115/408 - (28%)
Similarity:	177/408 - (43%)	Gaps:	72/408 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    71 KKFGADDKNEVKNKPAVPKNSLHLDLEKR----DLNGNFPKTNLKPG-----SPSDLENA----- 121
            :.||.|.::.:.::|..|.:........|    |.....|..:..||     |||....|
  Fly   210 RTFGPDGRSSLPSEPGFPHHLARSPSPMRTISLDARCGSPAHSADPGDLRTPSPSQSSLASLAGG 274

Human   122 ------------------TPKLFLEGEKESVSPESLKSS----------------TSLTSEEKQE 152
                              :|.|.....:..|.|....:|                ..||:.|...
  Fly   275 SGMGGSSAGKGVAGGRCLSPLLIPPRSQPGVDPAMGPASPLGALQPDLYRMPDGPVYLTAPESSH 339

Human   153 KLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMTILPE-KKHKVKTRVLRKTLD 216
            .:|.|...::|::......|::.||..|..::|... .|||:::.:.|| ...|.:|.:.|...:
  Fly   340 AVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEGGF-RDPYVRLMLQPEVDSRKRQTHIHRGESN 403

Human   217 PAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIELSE-----GKMLMNRE 276
            |.||:.|.| .:...|:|...|...:|.:||:|.:||||||.|.:.|::||:     |.:|
  Fly   404 PYFDQHFKF-PVSRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGLDLSKSVEIWGDLL---- 463

Human   277 IIKRNVRKSSGRGELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKK 341
               |..:....|.|||.||.|......||||::|||:|     ..|.:||||:.|....|||.||
  Fly   464 ---RTKKPKEDRPELLCSLNYLPQAERLTVVIMKARNL-----DTLQEPYVKIYLIQNGKRIKKK 520

Human   342 KTHVKKC--TPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGGEH 404
            ||.:.|.  ..|.::||.|.|::....|.:.::|..|:.:  ||....||...||....|||.:|
  Fly   521 KTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEIYVVGA--GSEATEIGCCGLGPQESGTGCQH 583

Human   405 WKEICDYPRRQIAKWHVL 422
            |.::.:..|:..|.||.:
  Fly   584 WHDMINNARKPTAMWHYI 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SYT4	NP_065834.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..93		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..147		4/35 (11%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	40/131 (31%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	52/137 (38%)
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	39/123 (32%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	51/134 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820