DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SYT4 and Syt12

DIOPT Version :9

Sequence 1:	NP_065834.1	Gene:	SYT4 / 6860	HGNCID:	11512	Length:	425	Species:	Homo sapiens
Sequence 2:	NP_001259513.1	Gene:	Syt12 / 32290	FlyBaseID:	FBgn0261085	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	351	Identity:	93/351 - (26%)
Similarity:	156/351 - (44%)	Gaps:	84/351 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   112 PGSPS--DLENATPKLFLEGEKESVSPESLKSSTSLTSEEKQEK----LGTLFFSLEY-----NF 165
            |||..  :||.|            :|.:|:.|.::|..::..:.    .|.|...|.|     :.
  Fly   446 PGSMDGINLERA------------ISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISN 498

Human   166 ERKAFVVNIKEARGL--PAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPAFDETFTFY-- 226
            |.....|::.||:||  |...|   :.|.::::.::|:....::|:|::.||.|:::|:|.|:
  Fly   499 EGMELTVSVLEAKGLICPFSVE---SLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDFWLH 560

Human   227 ---------------GIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPL-SGIELSEGKMLMNR 275
                           |..:|.|.|..:.              |||:..|: :.|.||:.
  Fly   561 KRQARHSLWFHLYHNGPAHTLIGEAEME--------------IGEMPRPITTWIPLSDS------ 605

Human   276 EIIKRNVRKSSGR-GELLISLCYQSTTNTLTVVVLKARHL--------PKSDVSGLSDPYVKVNL 331
                   ||.:.| |||:.||.|..|...||:||:|||:|        |:| ...:...:|||.|
  Fly   606 -------RKCNARWGELMFSLSYLPTAERLTIVVVKARNLKLDGEQPAPES-AETVHSVFVKVYL 662

Human   332 YHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNEVIGQLVLGAA 396
            ....:::.||:|.:|:...:.:|||..:|.:|...|....:...|. ....|....:|.:|.|:.
  Fly   663 MDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVF-GVTTSGVTPLGHIVAGSC 726

Human   397 AEGTGGEHWKEICDYPRRQIAKWHVL 422
            |.|.|..||.::....|:.:|.||||
  Fly   727 AVGKGLRHWHQMLSSLRKPVAMWHVL 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SYT4	NP_065834.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..93
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..147		4/19 (21%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	33/154 (21%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	48/144 (33%)
Syt12	NP_001259513.1	C2	503..602	CDD:278593	26/115 (23%)
Syt12	NP_001259513.1	C2B_Synaptotagmin-12	612..753	CDD:176051	47/143 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820