DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SYT1 and Sytalpha

DIOPT Version :9

Sequence 1:	NP_001129277.1	Gene:	SYT1 / 6857	HGNCID:	11509	Length:	422	Species:	Homo sapiens
Sequence 2:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	301	Identity:	109/301 - (36%)
Similarity:	173/301 - (57%)	Gaps:	12/301 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   120 KDDDAETGLTDGEEKEEPKE------EEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTS 178
            |.|..:..:|......:||.      .|..|.|..||.||.....|.|.:::|..|......||:
  Fly   190 KLDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTA 254

Human   179 DPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGE 243
            |||.||.||||||..::|::|::||||||:|||.|:|....:..:|:.:.:||||.:|:|..||.
  Fly   255 DPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGG 319

Human   244 FKVPMNTVDFGHVTEEWRDLQSAEKEEQE-KLGDICFSLRYVPTAGKLTVVILEAKNLKKM-DVG 306
            .|:.:..:|.....:.|..|.||..::.: .||||..||.|:|:|.:|.||:::|:||:.: |..
  Fly   320 SKLHLANLDLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDAR 384

Human   307 GLSDPYVKIHLM-QNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGK 370
            ..||||||:.|: ..||::||:||.:::.||||.|||:.:|:|..|.::...:..||:....:|.
  Fly   385 NSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGS 449

Human   371 NDAIGKVFVGYNS--TGAELRHWSDMLANPRRPIAQWHTLQ 409
            ::.:|:..:| ||  ...|.:.:.:.:...:...|||..||
  Fly   450 SEILGRTLIG-NSPEVRTEEKIFFEEVFRAKNATAQWVPLQ 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SYT1	NP_001129277.1	Syt1_N	6..113	CDD:409248
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142		5/27 (19%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		98/254 (39%)
		C2A_Synaptotagmin-1-5-6-9-10	143..265	CDD:176031	49/121 (40%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	50/138 (36%)
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	49/122 (40%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	49/136 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820